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Distinct motifs in the chemokine receptor CCR7 regulate signal transduction, receptor trafficking and chemotaxis

Distinct motifs in the chemokine receptor CCR7 regulate signal transduction, receptor trafficking and chemotaxis

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OTERO, Carolina, Petra S. EISELE, Karin SCHAUBLE, Marcus GROETTRUP, Daniel F. LEGLER, 2008. Distinct motifs in the chemokine receptor CCR7 regulate signal transduction, receptor trafficking and chemotaxis. In: Journal of cell science. 121(24), pp. 2759-2767. ISSN 0021-9533. eISSN 1477-9137

@article{Otero2008Disti-1249, title={Distinct motifs in the chemokine receptor CCR7 regulate signal transduction, receptor trafficking and chemotaxis}, year={2008}, doi={10.1242/jcs.029074}, number={24}, volume={121}, issn={0021-9533}, journal={Journal of cell science}, pages={2759--2767}, author={Otero, Carolina and Eisele, Petra S. and Schauble, Karin and Groettrup, Marcus and Legler, Daniel F.} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/1249"> <dcterms:issued>2008</dcterms:issued> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dc:contributor>Groettrup, Marcus</dc:contributor> <dc:creator>Legler, Daniel F.</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:07:25Z</dc:date> <dc:contributor>Schauble, Karin</dc:contributor> <dcterms:title>Distinct motifs in the chemokine receptor CCR7 regulate signal transduction, receptor trafficking and chemotaxis</dcterms:title> <dc:contributor>Otero, Carolina</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/1249"/> <dc:creator>Otero, Carolina</dc:creator> <dc:rights>deposit-license</dc:rights> <dc:creator>Eisele, Petra S.</dc:creator> <dc:contributor>Eisele, Petra S.</dc:contributor> <dc:creator>Schauble, Karin</dc:creator> <dc:contributor>Legler, Daniel F.</dc:contributor> <dcterms:bibliographicCitation>Publ. in: Journal of cell science 121 (2008), 24, pp. 2759-2767</dcterms:bibliographicCitation> <dcterms:abstract>The chemokine receptor CCR7, together with its ligands CCL19 and CCL21, is responsible for the correct homing and trafficking of dendritic cells and lymphocytes to secondary lymphoid tissues. Moreover, cancer cells can utilize CCR7 to metastasize to draining lymph nodes. However, information on CCR7 signaling leading to cell migration or receptor trafficking is sparse. Using novel CCR7 deletion mutants with successive truncations of the intracellular C-terminus and a mutant with impaired G-protein coupling, we identified distinct motifs responsible for various aspects of CCR7 signal transduction. Deleting a Ser/Thr motif at the tip of the intracellular tail of CCR7 resulted in an impaired chemokine-mediated activation of Erk1/2 kinases. Interestingly, deleting an additional adjacent motif restored the ability of CCL19-mediated Erk1/2 phosphorylation, suggesting the presence of a regulatory motif. Both the Ser/Thr and the regulatory motif are dispensable for signaling events leading to cell migration and receptor trafficking. A CCR7 mutant lacking virtually the complete C-terminus readily bound CCL19 and was internalized, but was unable to activate the G protein and to transmit signals required for cell migration, mobilization of [Ca2+](i) and Erk1/2 activation. Finally, G-protein coupling was critical for [Ca2+](i) mobilization, Erk1/2 phosphorylation and chemotaxis, but not for CCR7 trafficking.</dcterms:abstract> <dc:language>eng</dc:language> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:07:25Z</dcterms:available> <dc:creator>Groettrup, Marcus</dc:creator> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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