KOPS - Das Institutionelle Repositorium der Universität Konstanz

A novel peptide motif binding to and blocking the intracellular activity of the human papillomavirus E6 oncoprotein

A novel peptide motif binding to and blocking the intracellular activity of the human papillomavirus E6 oncoprotein

Zitieren

Dateien zu dieser Ressource

Dateien Größe Format Anzeige

Zu diesem Dokument gibt es keine Dateien.

DYMALLA, Susanne, Martin SCHEFFNER, Elvira WEBER, Peter SEHR, Claudia LOHREY, Felix HOPPE-SEYLER, Karin HOPPE-SEYLER, 2009. A novel peptide motif binding to and blocking the intracellular activity of the human papillomavirus E6 oncoprotein. In: Journal of Molecular Medicine. 87(3), pp. 321-331. ISSN 0946-2716. eISSN 1432-1440

@article{Dymalla2009novel-1248, title={A novel peptide motif binding to and blocking the intracellular activity of the human papillomavirus E6 oncoprotein}, year={2009}, doi={10.1007/s00109-008-0432-1}, number={3}, volume={87}, issn={0946-2716}, journal={Journal of Molecular Medicine}, pages={321--331}, author={Dymalla, Susanne and Scheffner, Martin and Weber, Elvira and Sehr, Peter and Lohrey, Claudia and Hoppe-Seyler, Felix and Hoppe-Seyler, Karin} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/1248"> <dc:creator>Scheffner, Martin</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/1248"/> <dc:contributor>Scheffner, Martin</dc:contributor> <dc:contributor>Dymalla, Susanne</dc:contributor> <dc:contributor>Lohrey, Claudia</dc:contributor> <dc:contributor>Weber, Elvira</dc:contributor> <dc:creator>Dymalla, Susanne</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:07:24Z</dcterms:available> <dc:contributor>Hoppe-Seyler, Felix</dc:contributor> <dc:creator>Hoppe-Seyler, Karin</dc:creator> <dc:creator>Hoppe-Seyler, Felix</dc:creator> <dc:rights>deposit-license</dc:rights> <dcterms:abstract>Specific types of human papillomaviruses (HPVs) cause cervical cancer. The viral E6 oncogene is a critical factor for maintaining the malignant phenotype of HPV-positive tumour cells. By yeast two-hybrid screening of a randomised peptide expression library, we isolated linear short peptides, which specifically bind to the HPV16 E6 oncoprotein. Sequence alignments and mutational analyses of the peptides identified a hitherto undiscovered E6-binding motif. Intracellular expression of a peptide containing the novel E6-binding motif resulted in inhibition of colony formation capacity, specifically of HPV16-positive cancer cells. A solubility-optimised variant of the peptide was created, which binds to HPV16 E6 with high affinity. Its intracellular expression efficiently induced apoptosis in HPV16-positive cancer cells. This was linked to restoration of intracellular p53 activities. Thus, this newly identified E6-binding motif could form a novel basis for the development of rational strategies for the treatment of HPV16-positive preneoplastic and neoplastic lesions.</dcterms:abstract> <dc:creator>Sehr, Peter</dc:creator> <dc:contributor>Hoppe-Seyler, Karin</dc:contributor> <dcterms:title>A novel peptide motif binding to and blocking the intracellular activity of the human papillomavirus E6 oncoprotein</dcterms:title> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:07:24Z</dc:date> <dc:creator>Weber, Elvira</dc:creator> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dcterms:bibliographicCitation>First publ. in: Journal of Molecular Medicine 87 (2009), 3, pp. 321-331</dcterms:bibliographicCitation> <dc:contributor>Sehr, Peter</dc:contributor> <dc:language>eng</dc:language> <dcterms:issued>2009</dcterms:issued> <dc:creator>Lohrey, Claudia</dc:creator> </rdf:Description> </rdf:RDF>

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto