KOPS - Das Institutionelle Repositorium der Universität Konstanz

Endogenous beta-Adrenergic Receptors Inhibit Lipopolysaccharide-Induced Pulmonary Cytokine Release and Coagulation

Endogenous beta-Adrenergic Receptors Inhibit Lipopolysaccharide-Induced Pulmonary Cytokine Release and Coagulation

Zitieren

Dateien zu dieser Ressource

Dateien Größe Format Anzeige

Zu diesem Dokument gibt es keine Dateien.

GIEBELEN, Ida A. J., Masja LEENDERTSE, Mark C. DESSING, Joost C. M. MEIJERS, Marcel LEVI, Christian DRAING, Sonja von AULOCK, Tom van der POLL, 2008. Endogenous beta-Adrenergic Receptors Inhibit Lipopolysaccharide-Induced Pulmonary Cytokine Release and Coagulation. In: American Journal of Respiratory Cell and Molecular Biology. 39(3), pp. 373-379. ISSN 1044-1549. eISSN 1535-4989. Available under: doi: 10.1165/rcmb.2007-0439OC

@article{Giebelen2008Endog-1223, title={Endogenous beta-Adrenergic Receptors Inhibit Lipopolysaccharide-Induced Pulmonary Cytokine Release and Coagulation}, year={2008}, doi={10.1165/rcmb.2007-0439OC}, number={3}, volume={39}, issn={1044-1549}, journal={American Journal of Respiratory Cell and Molecular Biology}, pages={373--379}, author={Giebelen, Ida A. J. and Leendertse, Masja and Dessing, Mark C. and Meijers, Joost C. M. and Levi, Marcel and Draing, Christian and Aulock, Sonja von and Poll, Tom van der} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/1223"> <dc:creator>Leendertse, Masja</dc:creator> <dc:creator>Levi, Marcel</dc:creator> <dc:creator>Poll, Tom van der</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:06:53Z</dc:date> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Meijers, Joost C. M.</dc:contributor> <dc:creator>Aulock, Sonja von</dc:creator> <dc:contributor>Dessing, Mark C.</dc:contributor> <dc:contributor>Leendertse, Masja</dc:contributor> <dcterms:abstract xml:lang="eng">β2-adrenergic receptors are expressed on different cell types in the lung, including respiratory epithelial cells, smooth muscle cells, and macrophages. The aim of the current study was to determine the role of β-adrenergic receptors in the regulation of lung inflammation induced by instillation via the airways of lipopolysaccharide (LPS) (a constituent of the gram-negative bacterial cell wall) or lipoteichoic acid (LTA) (a component of the gram-positive bacterial cell wall). Mice inhaled the β-adrenergic antagonist propranolol or saline 30 minutes before and 3 hours after intranasal LPS or LTA administration. LPS and LTA induced a profound inflammatory response in the lungs as reflected by an influx of neutrophils and the release of proinflammatory cytokines and chemokines into bronchoalveolar lavage fluid (BALF). Propranolol inhalation resulted in enhanced LPS-induced lung inflammation, which was reflected by a stronger secretion of TNF-, IL-6, and monocyte chemoattractant protein-1 into BALF and by enhanced coagulation activation (thrombin antithrombin complexes). In LTA-induced lung inflammation, propranolol did not influence cytokine release but potentiated activation of coagulation. Propranolol did not alter neutrophil recruitment in either model. This study suggests that β-adrenergic receptors, which are widely expressed in the lungs, serve as negative regulators of pulmonary cytokine release and coagulation induced by LPS and less so during LTA-induced pulmonary inflammation.</dcterms:abstract> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Dessing, Mark C.</dc:creator> <dc:creator>Draing, Christian</dc:creator> <dc:contributor>Draing, Christian</dc:contributor> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Giebelen, Ida A. J.</dc:contributor> <dc:contributor>Aulock, Sonja von</dc:contributor> <dc:contributor>Poll, Tom van der</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:06:53Z</dcterms:available> <dc:contributor>Levi, Marcel</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/1223"/> <dc:creator>Meijers, Joost C. M.</dc:creator> <dc:language>eng</dc:language> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dcterms:issued>2008</dcterms:issued> <dc:rights>deposit-license</dc:rights> <dcterms:title>Endogenous beta-Adrenergic Receptors Inhibit Lipopolysaccharide-Induced Pulmonary Cytokine Release and Coagulation</dcterms:title> <dc:creator>Giebelen, Ida A. J.</dc:creator> <dcterms:bibliographicCitation>Publ. in: American Journal of Respiratory Cell and Molecular Biology 39 (2008), 3, pp. 373-379</dcterms:bibliographicCitation> </rdf:Description> </rdf:RDF>

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto