Type of Publication: | Journal article |
Author: | Groettrup, Marcus; Pelzer, Christiane; Schmidtke, Gunter; Hofmann, Kay |
Year of publication: | 2008 |
Published in: | Trends in Biochemical Sciences ; 33 (2008), 5. - pp. 230-237. - ISSN 0968-0004 |
Pubmed ID: | 18353650 |
DOI (citable link): | https://dx.doi.org/10.1016/j.tibs.2008.01.005 |
Summary: |
Since its discovery in 1981, ubiquitin-activating enzyme 1 was thought to be the only E1-type enzyme responsible for ubiquitin activation. Recently, a relatively uncharacterized E1 enzyme, designated ubiquitin-like modifier activating enzyme 6, was also shown to activate ubiquitin. Ubiquitin-activating enzyme 1 and ubiquitin-like modifier activating enzyme 6 are both essential proteins, and each uses a different spectrum of ubiquitin-conjugating (E2) enzymes. Ubiquitin-like modifier activating enzyme 6 activates not only ubiquitin, but also the ubiquitin-like modifier FAT10 (human leukocyte antigen F-associated transcript 10), which, similarly to ubiquitin, serves as a signal for proteasomal degradation. This new layer of regulation in ubiquitin activation markedly increases the versatility of the ubiquitin conjugation system.
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Subject (DDC): | 570 Biosciences, Biology |
Bibliography of Konstanz: | Yes |
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GROETTRUP, Marcus, Christiane PELZER, Gunter SCHMIDTKE, Kay HOFMANN, 2008. Activating the ubiquitin family : UBA6 challenges the field. In: Trends in Biochemical Sciences. 33(5), pp. 230-237. ISSN 0968-0004. Available under: doi: 10.1016/j.tibs.2008.01.005
@article{Groettrup2008Activ-1219, title={Activating the ubiquitin family : UBA6 challenges the field}, year={2008}, doi={10.1016/j.tibs.2008.01.005}, number={5}, volume={33}, issn={0968-0004}, journal={Trends in Biochemical Sciences}, pages={230--237}, author={Groettrup, Marcus and Pelzer, Christiane and Schmidtke, Gunter and Hofmann, Kay} }
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