KOPS - Das Institutionelle Repositorium der Universität Konstanz

A novel cytosolic class I antigen-processing pathway for endoplasmic-reticulum-targeted proteins

A novel cytosolic class I antigen-processing pathway for endoplasmic-reticulum-targeted proteins

Zitieren

Dateien zu dieser Ressource

Prüfsumme: MD5:fdea68c5f479635bd67a092d2e679816

SCHLOSSER, Eva Christine, Carolina OTERO, Christine WUENSCH, Benedikt KESSLER, Mariola EDELMANN, René BRUNISHOLZ, Ingo DREXLER, Daniel F. LEGLER, Marcus GROETTRUP, 2007. A novel cytosolic class I antigen-processing pathway for endoplasmic-reticulum-targeted proteins. In: EMBO reports. 8(10), pp. 945-951. ISSN 1469-221X. eISSN 1469-3178. Available under: doi: 10.1038/sj.embor.7401065

@article{Schlosser2007novel-1202, title={A novel cytosolic class I antigen-processing pathway for endoplasmic-reticulum-targeted proteins}, year={2007}, doi={10.1038/sj.embor.7401065}, number={10}, volume={8}, issn={1469-221X}, journal={EMBO reports}, pages={945--951}, author={Schlosser, Eva Christine and Otero, Carolina and Wuensch, Christine and Kessler, Benedikt and Edelmann, Mariola and Brunisholz, René and Drexler, Ingo and Legler, Daniel F. and Groettrup, Marcus} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/1202"> <dc:contributor>Brunisholz, René</dc:contributor> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/1202/1/Schlosser_opus-85109.pdf"/> <dc:creator>Wuensch, Christine</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>Groettrup, Marcus</dc:contributor> <dc:creator>Schlosser, Eva Christine</dc:creator> <dcterms:title>A novel cytosolic class I antigen-processing pathway for endoplasmic-reticulum-targeted proteins</dcterms:title> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/1202/1/Schlosser_opus-85109.pdf"/> <dc:creator>Otero, Carolina</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/1202"/> <dc:contributor>Otero, Carolina</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:06:48Z</dcterms:available> <dc:contributor>Drexler, Ingo</dc:contributor> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:rights>deposit-license</dc:rights> <dc:contributor>Wuensch, Christine</dc:contributor> <dc:creator>Kessler, Benedikt</dc:creator> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Brunisholz, René</dc:creator> <dc:creator>Legler, Daniel F.</dc:creator> <dcterms:bibliographicCitation>Publ. in: EMBO reports 8 (2007), 10, pp. 945-951</dcterms:bibliographicCitation> <dc:creator>Drexler, Ingo</dc:creator> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dc:creator>Groettrup, Marcus</dc:creator> <dc:language>eng</dc:language> <dc:creator>Edelmann, Mariola</dc:creator> <dc:contributor>Edelmann, Mariola</dc:contributor> <dc:contributor>Legler, Daniel F.</dc:contributor> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:abstract>Proteins bearing an endoplasmic reticulum (ER) leader are inserted into the ER followed by cleavage of the signal peptide. Major histocompatibility complex class I-restricted T-cell epitopes can be generated from these proteins by the proteasome after retrotranslocation into the cytosol. Here, we show that an HLA-A(*)0201-restricted epitope from prostate stem cell antigen contains the cleavage site of the ER signal peptidase. The resulting cleavage products fail to bind to HLA-A(*)0201 and are not recognized by T lymphocytes. As processing of prostate stem cell antigen by signal peptidase occurs immediately after co-translational insertion, the epitope must be processed from polypeptides that have never reached the ER. The processing of this epitope depends on the proteasome and the transporter associated with antigen processing and shows a novel pathway of class I processing that relies on the failure of ER-targeted proteins to reach their target compartment.</dcterms:abstract> <dc:contributor>Schlosser, Eva Christine</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:06:48Z</dc:date> <dcterms:issued>2007</dcterms:issued> <dc:contributor>Kessler, Benedikt</dc:contributor> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

Schlosser_opus-85109.pdf 16

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto