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Comparison of the skin sensitizing potential of unsaturated compounds as assessed by the murine local lymph node assay (LLNA) and the guinea pig maximization test (GPMT)

Comparison of the skin sensitizing potential of unsaturated compounds as assessed by the murine local lymph node assay (LLNA) and the guinea pig maximization test (GPMT)

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KREILING, Reinhard, Heli Miriam HOLLNAGEL, Lars HARENG, Dorothea EIGLER, Moung Sook LEE, Peter GRIEM, Birte DREESSEN, Marcus KLEBER, Achim ALBRECHT, Christine GARCIA, Albrecht WENDEL, 2008. Comparison of the skin sensitizing potential of unsaturated compounds as assessed by the murine local lymph node assay (LLNA) and the guinea pig maximization test (GPMT). In: Food and Chemical Toxicology. 46(6), pp. 1896-1904. ISSN 0278-6915. Available under: doi: 10.1016/j.fct.2008.01.019

@article{Kreiling2008Compa-1196, title={Comparison of the skin sensitizing potential of unsaturated compounds as assessed by the murine local lymph node assay (LLNA) and the guinea pig maximization test (GPMT)}, year={2008}, doi={10.1016/j.fct.2008.01.019}, number={6}, volume={46}, issn={0278-6915}, journal={Food and Chemical Toxicology}, pages={1896--1904}, author={Kreiling, Reinhard and Hollnagel, Heli Miriam and Hareng, Lars and Eigler, Dorothea and Lee, Moung Sook and Griem, Peter and Dreeßen, Birte and Kleber, Marcus and Albrecht, Achim and Garcia, Christine and Wendel, Albrecht} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/1196"> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dc:contributor>Hareng, Lars</dc:contributor> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Hollnagel, Heli Miriam</dc:creator> <dcterms:title>Comparison of the skin sensitizing potential of unsaturated compounds as assessed by the murine local lymph node assay (LLNA) and the guinea pig maximization test (GPMT)</dcterms:title> <dc:creator>Griem, Peter</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Kreiling, Reinhard</dc:creator> <dc:creator>Dreeßen, Birte</dc:creator> <dc:contributor>Wendel, Albrecht</dc:contributor> <dc:creator>Eigler, Dorothea</dc:creator> <dc:creator>Hareng, Lars</dc:creator> <dc:creator>Lee, Moung Sook</dc:creator> <dc:contributor>Dreeßen, Birte</dc:contributor> <dc:contributor>Griem, Peter</dc:contributor> <dc:contributor>Lee, Moung Sook</dc:contributor> <dc:creator>Wendel, Albrecht</dc:creator> <dc:contributor>Eigler, Dorothea</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/1196"/> <dc:rights>deposit-license</dc:rights> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:06:46Z</dc:date> <dcterms:abstract xml:lang="eng">The skin sensitization potential of eight unsaturated and one saturated lipid (bio)chemicals was tested in both the LLNA and the GPMT to address the hypothesis that chemicals with unsaturated carbon carbon double bonds may result in a higher number of unspecific (false positive) results in the LLNA compared to the GPMT. Seven substances (oleic acid, linoleic acid, linolenic acid, undecylenic acid, maleic acid, squalene and octinol) gave clear positive results in the LLNA (stimulation index (SI) 3) and thus would require labelling as skin sensitizer. Fumaric acid and succinic acid gave clearly negative results. In the GPMT, besides some sporadic skin reactions, reproducible skin reactions indicating an allergic response were found in a few animals for four test substances. Based on the GPMT results, only undecylenic acid would have to be classified and labelled as a skin sensitizer according to the European Dangerous Substance Directive (67/548/EEC) (results for linoleic acid were inconclusive), while the other seven test substances would not require labelling. Possible mechanisms for unspecific skin cell stimulation and lymph node responses are discussed. In conclusion, the suitability of the LLNA for unsaturated compounds bearing structural similarity to the tested substances should be carefully considered and the GPMT should remain available as an accepted test method for skin sensitization hazard identification.</dcterms:abstract> <dcterms:issued>2008</dcterms:issued> <dc:contributor>Garcia, Christine</dc:contributor> <dc:creator>Kleber, Marcus</dc:creator> <dc:creator>Garcia, Christine</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Kleber, Marcus</dc:contributor> <dc:contributor>Albrecht, Achim</dc:contributor> <dc:creator>Albrecht, Achim</dc:creator> <dcterms:bibliographicCitation>Publ. in: Food and Chemical Toxicology 46 (2008), 6, pp. 1896-1904</dcterms:bibliographicCitation> <dc:contributor>Kreiling, Reinhard</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:06:46Z</dcterms:available> <dc:language>eng</dc:language> <dc:contributor>Hollnagel, Heli Miriam</dc:contributor> </rdf:Description> </rdf:RDF>

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