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Lipoteichoic Acid-Induced Lung Inflammation Depends on TLR2 and the Concerted Action of TLR4 and the Platelet-Activating Factor Receptor

Lipoteichoic Acid-Induced Lung Inflammation Depends on TLR2 and the Concerted Action of TLR4 and the Platelet-Activating Factor Receptor

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KNAPP, Sylvia, Sonja von AULOCK, Masja LEENDERTSE, Isabella HASLINGER, Christian DRAING, Douglas T. GOLENBOCK, Tom van der POLL, 2008. Lipoteichoic Acid-Induced Lung Inflammation Depends on TLR2 and the Concerted Action of TLR4 and the Platelet-Activating Factor Receptor. In: The Journal of Immunology. 180(5), pp. 3478-3484. ISSN 0022-1767. eISSN 1550-6606

@article{Knapp2008Lipot-1184, title={Lipoteichoic Acid-Induced Lung Inflammation Depends on TLR2 and the Concerted Action of TLR4 and the Platelet-Activating Factor Receptor}, year={2008}, doi={10.4049/jimmunol.180.5.3478}, number={5}, volume={180}, issn={0022-1767}, journal={The Journal of Immunology}, pages={3478--3484}, author={Knapp, Sylvia and Aulock, Sonja von and Leendertse, Masja and Haslinger, Isabella and Draing, Christian and Golenbock, Douglas T. and Poll, Tom van der} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/1184"> <dc:contributor>Draing, Christian</dc:contributor> <dc:language>eng</dc:language> <dcterms:issued>2008</dcterms:issued> <dc:contributor>Leendertse, Masja</dc:contributor> <dcterms:title>Lipoteichoic Acid-Induced Lung Inflammation Depends on TLR2 and the Concerted Action of TLR4 and the Platelet-Activating Factor Receptor</dcterms:title> <dcterms:bibliographicCitation>Publ. in: The Journal of Immunology 180 (2008), 5, pp. 3478-3484</dcterms:bibliographicCitation> <dc:contributor>Poll, Tom van der</dc:contributor> <dc:contributor>Knapp, Sylvia</dc:contributor> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dc:contributor>Golenbock, Douglas T.</dc:contributor> <dc:contributor>Aulock, Sonja von</dc:contributor> <dcterms:abstract xml:lang="eng">Lipoteichoic acid (LTA) is a major outer cell wall component of Gram-positive bacteria that has been implicated as an important factor in the inflammatory response following bacterial infection. In vitro data indicate roles for TLR2, platelet-activating factor receptor (PAFR), CD14, and LPS-binding protein (LBP) in cellular responsiveness to LTA, whereas the mechanisms contributing to LTA effects in vivo have never been investigated. Using mice deficient for LBP, CD14, TLR2, TLR4, or PAFR, we now examined the role of these molecules in pulmonary inflammation induced by highly purified LTA in vivo. Although pulmonary LBP increased dose-dependently following administration of LTA, the inflammatory response was unaltered in LBP / mice. TLR2 proved to be indispensable for the initiation of an inflammatory response, as polymorphonuclear cell influx, TNF-, keratinocyte-derived chemokine, and MIP-2 release were abolished in TLR2 / mice. Minor effects such as moderately decreased TNF- and MIP-2 levels were observed in the absence of CD14, indicating a role for CD14 as a coreceptor. Quite surprisingly, the absence of TLR4 greatly diminished pulmonary inflammation and the same phenotype was observed in PAFR / animals. In contrast to all other mice studied, only TLR4 / and PAFR / mice displayed significantly elevated IL-10 pulmonary concentrations. These data suggest that TLR2 is the single most important receptor signaling the presence of LTA within the lungs in vivo, whereas TLR4 and PAFR may influence lung inflammation induced by LTA either by sensing LTA directly or through recognition and signaling of endogenous mediators induced by the interaction between LTA and TLR2.</dcterms:abstract> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/1184"/> <dc:creator>Draing, Christian</dc:creator> <dc:creator>Leendertse, Masja</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:06:41Z</dc:date> <dc:rights>deposit-license</dc:rights> <dc:creator>Golenbock, Douglas T.</dc:creator> <dc:creator>Poll, Tom van der</dc:creator> <dc:creator>Haslinger, Isabella</dc:creator> <dc:contributor>Haslinger, Isabella</dc:contributor> <dc:creator>Knapp, Sylvia</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:06:41Z</dcterms:available> <dc:creator>Aulock, Sonja von</dc:creator> </rdf:Description> </rdf:RDF>

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