Proteasomes in immune cells : more than peptide producers?

Zitieren

Dateien zu dieser Ressource

Dateien Größe Format Anzeige

Zu diesem Dokument gibt es keine Dateien.

GROETTRUP, Marcus, Christopher J. KIRK, Michael BASLER, 2010. Proteasomes in immune cells : more than peptide producers?. In: Nature Reviews Immunology. 10(1), pp. 73-78. ISSN 1474-1733. eISSN 1474-1741. Available under: doi: 10.1038/nri2687

@article{Groettrup2010Prote-1161, title={Proteasomes in immune cells : more than peptide producers?}, year={2010}, doi={10.1038/nri2687}, number={1}, volume={10}, issn={1474-1733}, journal={Nature Reviews Immunology}, pages={73--78}, author={Groettrup, Marcus and Kirk, Christopher J. and Basler, Michael} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/1161"> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:06:33Z</dc:date> <dcterms:title>Proteasomes in immune cells : more than peptide producers?</dcterms:title> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dc:contributor>Kirk, Christopher J.</dc:contributor> <dc:contributor>Groettrup, Marcus</dc:contributor> <dcterms:bibliographicCitation>Publ. in: Nature Reviews Immunology 10 (2010), 1, pp. 73-78</dcterms:bibliographicCitation> <dcterms:abstract xml:lang="eng">When cells are stimulated with pro-inflammatory cytokines, most of their constitutively expressed proteasomes are replaced with immunoproteasomes, which increase the production of peptides for presentation on MHC class I molecules. In addition, cortical thymic epithelial cells selectively express a type of proteasome known as the thymoproteasome that is required for the positive selection of thymocytes. Here, we discuss how these specialized types of proteasome shape the T cell receptor repertoire of cytotoxic T lymphocytes and propose that immunoproteasomes have functions, in addition to antigen processing, that influence cytokine production and T cell differentiation, survival and function. We also discuss how inhibitors of immunoproteasomes can suppress undesired T cell responses in autoimmune diseases.</dcterms:abstract> <dc:creator>Basler, Michael</dc:creator> <dc:creator>Kirk, Christopher J.</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:06:33Z</dcterms:available> <dc:contributor>Basler, Michael</dc:contributor> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:issued>2010</dcterms:issued> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/1161"/> <dc:language>eng</dc:language> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Groettrup, Marcus</dc:creator> <dc:rights>deposit-license</dc:rights> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> </rdf:Description> </rdf:RDF>

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto