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Aging of different avian cultured cells : lack of ROS-induced damage and quality control mechanisms

Aging of different avian cultured cells : lack of ROS-induced damage and quality control mechanisms

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STRECKER, Valentina, Sören MAI, Britta MUSTER, Sascha BENEKE, Alexander BÜRKLE, Jürgen BEREITER-HAHN, Marina JENDRACH, 2010. Aging of different avian cultured cells : lack of ROS-induced damage and quality control mechanisms. In: Mechanisms of Ageing and Development. 131(1), pp. 48-59. ISSN 0047-6374. eISSN 1872-6216

@article{Strecker2010Aging-1158, title={Aging of different avian cultured cells : lack of ROS-induced damage and quality control mechanisms}, year={2010}, doi={10.1016/j.mad.2009.11.005}, number={1}, volume={131}, issn={0047-6374}, journal={Mechanisms of Ageing and Development}, pages={48--59}, author={Strecker, Valentina and Mai, Sören and Muster, Britta and Beneke, Sascha and Bürkle, Alexander and Bereiter-Hahn, Jürgen and Jendrach, Marina} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/1158"> <dc:creator>Beneke, Sascha</dc:creator> <dc:contributor>Bürkle, Alexander</dc:contributor> <dc:creator>Strecker, Valentina</dc:creator> <dc:contributor>Jendrach, Marina</dc:contributor> <dcterms:abstract xml:lang="eng">Elevated reactive oxygen species (ROS) levels have been observed in mammals during aging, implying an important role of ROS in the aging process. Most bird species are known to live longer and to contain lower ROS levels than mammals of the same body weight. The influence of ROS on the aging process of birds has been investigated using pigeon embryonic fibroblasts (PEF) and chicken embryonic fibroblasts (CEF). ROS levels in young avian cells were much lower than in human cells. When cultivated till replicative senescence, PEF proliferated about one-third longer compared to CEF. However, both senescent avian cell populations showed no increased ROS levels or accumulation of ROS-induced damage on the mtDNA or protein level. The investigation for quality control (QC) mechanisms revealed that the autophagosomal/lysosomal pathway was not downregulated in old avian cells and stable overexpression of the autophagy protein ATG5 improved mitochondrial fitness, enhanced the resistance against oxidative stress and prolonged the life span of CEF. Oxidative stress-mediated apoptosis induced a dose-dependent cell proliferation in CEF as well as in PEF. Taken together, our data indicate that autophagy and compensatory proliferation act as QC mechanisms, while ROS did not influence the aging process in avian cells.</dcterms:abstract> <dc:creator>Bereiter-Hahn, Jürgen</dc:creator> <dc:creator>Muster, Britta</dc:creator> <dc:contributor>Strecker, Valentina</dc:contributor> <dcterms:title>Aging of different avian cultured cells : lack of ROS-induced damage and quality control mechanisms</dcterms:title> <dc:rights>deposit-license</dc:rights> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:06:31Z</dc:date> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:06:31Z</dcterms:available> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/1158"/> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dc:creator>Mai, Sören</dc:creator> <dc:contributor>Beneke, Sascha</dc:contributor> <dc:creator>Jendrach, Marina</dc:creator> <dc:creator>Bürkle, Alexander</dc:creator> <dc:contributor>Mai, Sören</dc:contributor> <dc:contributor>Bereiter-Hahn, Jürgen</dc:contributor> <dc:language>eng</dc:language> <dc:contributor>Muster, Britta</dc:contributor> <dcterms:bibliographicCitation>Publ. in: Mechanisms of Ageing and Development 131 (2010), 1, pp. 48-59</dcterms:bibliographicCitation> <dcterms:issued>2010</dcterms:issued> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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