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Linking membrane microdomains to the cytoskeleton : regulation of the lateral mobility of reggie-1/flotillin-2 by interaction with actin

Linking membrane microdomains to the cytoskeleton : regulation of the lateral mobility of reggie-1/flotillin-2 by interaction with actin

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LANGHORST, Matthias F., Gonzalo SOLIS PADILLA, Sylvia HANNBECK, Helmut PLATTNER, Claudia STÜRMER, 2007. Linking membrane microdomains to the cytoskeleton : regulation of the lateral mobility of reggie-1/flotillin-2 by interaction with actin. In: FEBS Letters. 581(24), pp. 4704-4710. ISSN 0014-5793

@article{Langhorst2007-10-02Linki-1146, title={Linking membrane microdomains to the cytoskeleton : regulation of the lateral mobility of reggie-1/flotillin-2 by interaction with actin}, year={2007}, doi={10.1016/j.febslet.2007.08.066}, number={24}, volume={581}, issn={0014-5793}, journal={FEBS Letters}, pages={4704--4710}, author={Langhorst, Matthias F. and Solis Padilla, Gonzalo and Hannbeck, Sylvia and Plattner, Helmut and Stürmer, Claudia} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/1146"> <dc:creator>Solis Padilla, Gonzalo</dc:creator> <dc:creator>Hannbeck, Sylvia</dc:creator> <dcterms:issued>2007-10-02</dcterms:issued> <dc:creator>Stürmer, Claudia</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/1146"/> <dc:contributor>Langhorst, Matthias F.</dc:contributor> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dc:creator>Plattner, Helmut</dc:creator> <dc:rights>deposit-license</dc:rights> <dc:creator>Langhorst, Matthias F.</dc:creator> <dc:contributor>Stürmer, Claudia</dc:contributor> <dcterms:bibliographicCitation>Publ. in: FEBS Letters ; 581 (2007), 24. - S. 4697-4703</dcterms:bibliographicCitation> <dcterms:title>Linking membrane microdomains to the cytoskeleton : regulation of the lateral mobility of reggie-1/flotillin-2 by interaction with actin</dcterms:title> <dcterms:abstract xml:lang="eng">The reggies/flotillins are oligomeric scaffolding proteins for membrane microdomains. We show here that reggie-1/flotillin-2 microdomains are organized along cortical F-actin in several cell types. Interaction with F-actin is mediated by the SPFH domain as shown by in vivo co-localization and in vitro binding experiments. Reggie-1/flotillin-2 microdomains form independent of actin, but disruption or stabilization of the actin cytoskeleton modulate the lateral mobility of reggie-1/flotillin-2 as shown by FRAP. Furthermore, reggie/flotillin microdomains can efficiently be immobilized by actin polymerisation, while exchange of reggie-1/flotillin-2 molecules between microdomains is enhanced by actin disruption as shown by tracking of individual microdomains using TIRF microscopy.</dcterms:abstract> <dc:contributor>Solis Padilla, Gonzalo</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:06:27Z</dc:date> <dc:language>eng</dc:language> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:06:27Z</dcterms:available> <dc:contributor>Plattner, Helmut</dc:contributor> <dc:contributor>Hannbeck, Sylvia</dc:contributor> </rdf:Description> </rdf:RDF>

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