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Zebrafish Neurolin-a and -b, Orthologs of ALCAM, are Involved in Retinal Ganglion Cell Differentiation and Retinal Axon Pathfinding

Zebrafish Neurolin-a and -b, Orthologs of ALCAM, are Involved in Retinal Ganglion Cell Differentiation and Retinal Axon Pathfinding

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DIEKMANN, Heike, Claudia STÜRMER, 2009. Zebrafish Neurolin-a and -b, Orthologs of ALCAM, are Involved in Retinal Ganglion Cell Differentiation and Retinal Axon Pathfinding. In: Journal of Comparative Neurology. 513(1), pp. 38-50. ISSN 0021-9967. eISSN 1096-9861. Available under: doi: 10.1002/cne.21928

@article{Diekmann2009Zebra-1139, title={Zebrafish Neurolin-a and -b, Orthologs of ALCAM, are Involved in Retinal Ganglion Cell Differentiation and Retinal Axon Pathfinding}, year={2009}, doi={10.1002/cne.21928}, number={1}, volume={513}, issn={0021-9967}, journal={Journal of Comparative Neurology}, pages={38--50}, author={Diekmann, Heike and Stürmer, Claudia} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/1139"> <dc:contributor>Diekmann, Heike</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:06:24Z</dcterms:available> <dc:creator>Diekmann, Heike</dc:creator> <dc:rights>terms-of-use</dc:rights> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/1139/1/Stuermer_111801.pdf"/> <dc:contributor>Stürmer, Claudia</dc:contributor> <dcterms:title>Zebrafish Neurolin-a and -b, Orthologs of ALCAM, are Involved in Retinal Ganglion Cell Differentiation and Retinal Axon Pathfinding</dcterms:title> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/1139/1/Stuermer_111801.pdf"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:bibliographicCitation>Journal of Comparative Neurology ; 513 (2009), 1. - S. 38-50</dcterms:bibliographicCitation> <dc:creator>Stürmer, Claudia</dc:creator> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/1139"/> <dc:language>eng</dc:language> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:abstract xml:lang="eng">Neurolin-a and Neurolin-b (also called alcam and nlcam, respectively) are zebrafish orthologs of human ALCAM, an adhesion protein of the immunoglobulin superfamily with functions in axon growth and guidance. Within the developing zebrafish retina, onset and progression of Neurolin-a expression parallels the pattern of retinal ganglion cell (RGC) differentiation. By using a morpholino-based knockdown approach, we show that Neurolin-a (but not Neurolin-b) is necessary for a crucial step in RGC differentiation. Without Neurolin-a, a large proportion of RGCs fail to develop, and RGC axons are absent or reduced in number. Subsequently, Neurolin-a is required for RGC survival and for the differentiation of all other retinal neurons. Neurolin-b is expressed later in well-differentiated RGCs and is required for RGC axon pathfinding. Without Neurolin-b, RGC axons grow in highly aberrant routes along the optic tract and/or fail to reach the optic tectum. Thus, the zebrafish Neurolin paralogs are involved in distinct steps of retinotectal development.</dcterms:abstract> <dcterms:rights rdf:resource="https://kops.uni-konstanz.de/page/termsofuse"/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:06:24Z</dc:date> <dcterms:issued>2009</dcterms:issued> </rdf:Description> </rdf:RDF>

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