Stress load during childhood affects psychopathology in psychiatric patients

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WEBER, Katja, Brigitte ROCKSTROH, Jens BORGELT, Barbara AWISZUS, Tzvetan POPOV, Klaus HOFFMANN, Klaus SCHONAUER, Hans WATZL, Karl PRÖPSTER, 2008. Stress load during childhood affects psychopathology in psychiatric patients. In: BMC Psychiatry. 8(63). Available under: doi: 10.1186/1471-244X-8-63

@article{Weber2008Stres-11265, title={Stress load during childhood affects psychopathology in psychiatric patients}, year={2008}, doi={10.1186/1471-244X-8-63}, number={63}, volume={8}, journal={BMC Psychiatry}, author={Weber, Katja and Rockstroh, Brigitte and Borgelt, Jens and Awiszus, Barbara and Popov, Tzvetan and Hoffmann, Klaus and Schonauer, Klaus and Watzl, Hans and Pröpster, Karl} }

2008 Pröpster, Karl Awiszus, Barbara Hoffmann, Klaus Hoffmann, Klaus 2011-03-25T09:27:12Z Weber, Katja Schonauer, Klaus Watzl, Hans eng Stress load during childhood affects psychopathology in psychiatric patients Background:<br />Childhood stress and trauma have been related to adult psychopathology in different psychiatric disorders. The present study aimed at verifying this relationship for stressful experiences during developmental periods by screening stress load across life in adult psychiatric inpatients with different diagnoses compared to healthy subjects. In addition, a relationship between the amount of adverse experiences and the severity of pathology, which has been described as a 'building block' effect in posttraumatic stress disorder (PTSD), was explored for nontraumatic events in psychiatric disorders other than PTSD.<br /><br />Methods:<br />96 patients with diagnoses of Major Depressive Disorder (MDD), schizophrenia, drug addiction, or personality disorders (PD) and 31 subjects without psychiatric diagnosis were screened for adverse experiences in childhood (before the age of six years), before onset of puberty, and in adulthood using the Early Trauma Inventory and the Posttraumatic Stress Diagnostic Scale. Effects of stress load on psychopathology were examined for affective symptoms, PTSD, and severity of illness by regression analyses and comparison of subgroups with high and low stress load.<br /><br />Results:<br />High stress load in childhood and before puberty, but not in adulthood, was related to negative affect in all participants. In patients, high stress load was related to depressive and posttraumatic symptoms, severity of disorder, and the diagnoses of MDD and PD.<br /><br />Conclusion:<br />Results support the hypothesis of stress-sensitive periods during development, which may interact with genetic and other vulnerability factors in their influence on the progress of psychiatric disorders. A 'dose' effect of stress load on the severity of psychopathology is not restricted to the relationship between traumata and PTSD. Borgelt, Jens Borgelt, Jens Weber, Katja Awiszus, Barbara Popov, Tzvetan Popov, Tzvetan Watzl, Hans Rockstroh, Brigitte Schonauer, Klaus Pröpster, Karl First publ. in: BMC Psychiatry 2008, 8:63 application/pdf Rockstroh, Brigitte 2011-03-25T09:27:12Z deposit-license

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