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Abnormal oscillatory brain dynamics in schizophrenia : a sign of deviant communication in neural network?

Abnormal oscillatory brain dynamics in schizophrenia : a sign of deviant communication in neural network?

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Prüfsumme: MD5:b84d41078fbdda1ae089b36a6fa5b09e

ROCKSTROH, Brigitte S., Christian WIENBRUCH, William J. RAY, Thomas ELBERT, 2007. Abnormal oscillatory brain dynamics in schizophrenia : a sign of deviant communication in neural network?. In: BMC Psychiatry. 7(1), 44. ISSN 1471-244X. eISSN 1471-244X

@article{Rockstroh2007Abnor-11209, title={Abnormal oscillatory brain dynamics in schizophrenia : a sign of deviant communication in neural network?}, year={2007}, doi={10.1186/1471-244X-7-44}, number={1}, volume={7}, issn={1471-244X}, journal={BMC Psychiatry}, author={Rockstroh, Brigitte S. and Wienbruch, Christian and Ray, William J. and Elbert, Thomas}, note={Article Number: 44} }

2007 Rockstroh, Brigitte S. eng Ray, William J. BMC Psychiatry ; 7 (2007). - 44 2011-03-25T09:26:22Z Elbert, Thomas 2011-03-25T09:26:22Z deposit-license Rockstroh, Brigitte S. Abnormal oscillatory brain dynamics in schizophrenia : a sign of deviant communication in neural network? Wienbruch, Christian Background: Slow waves in the delta (0.5 - 4 Hz) frequency range are indications of normal activity in sleep. In neurological disorders, focal electric and magnetic slow wave activity is generated in the vicinity of structural brain lesions. Initial studies, including our own, suggest that the distribution of the focal concentration of generators of slow waves (dipole density in the delta frequency band) also distinguishes patients with psychiatric disorders such as schizophrenia, affective disorders, and posttraumatic stress disorder.<br /><br /><br />Methods: The present study examined the distribution of focal slow wave activity (ASWA: abnormal slow wave activity) in 116 healthy subjects, 76 inpatients with schizophrenic or schizoaffective diagnoses and 42 inpatients with affective (ICD-10: F3) or neurotic/reactive (F4) diagnoses using a newly refined measure of dipole density. Based on 5-min resting magnetoencephalogram (MEG), sources of activity in the 1-4 Hz frequency band were determined by equivalent dipole fitting in anatomically defined cortical regions.<br /><br /><br />Results: Compared to healthy subjects the schizophrenia sample was characterized by significantly more intense slow wave activity, with maxima in frontal and central areas. In contrast, affective disorder patients exhibited less slow wave generators mainly in frontal and central regions when compared to healthy subjects and schizophrenia patients. In both samples, frontal ASWA were related to affective symptoms.<br /><br /><br />Conclusion: In schizophrenic patients, the regions of ASWA correspond to those identified for gray matter loss. This suggests that ASWA might be evaluted as a measure of altered neuronal network architecture and communication, which may mediate psychophathological signs. Elbert, Thomas application/pdf Ray, William J. Wienbruch, Christian

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