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MEG gamma band activity in schizophrenia patients and healthy subjects in a mental arithmetic task and at rest

MEG gamma band activity in schizophrenia patients and healthy subjects in a mental arithmetic task and at rest

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Prüfsumme: MD5:e7e0303371775be7a312e19347e5c6e1

KISSLER, Johanna, Matthias M. MÜLLER, Thorsten FEHR, Brigitte ROCKSTROH, Thomas ELBERT, 2000. MEG gamma band activity in schizophrenia patients and healthy subjects in a mental arithmetic task and at rest. In: Clinical Neurophysiology. 111, pp. 2079-2087

@article{Kissler2000gamma-11197, title={MEG gamma band activity in schizophrenia patients and healthy subjects in a mental arithmetic task and at rest}, year={2000}, doi={10.1016/S1388-2457(00)00425-9}, volume={111}, journal={Clinical Neurophysiology}, pages={2079--2087}, author={Kissler, Johanna and Müller, Matthias M. and Fehr, Thorsten and Rockstroh, Brigitte and Elbert, Thomas} }

2011-03-25T09:26:17Z deposit-license Fehr, Thorsten Rockstroh, Brigitte Elbert, Thomas Kissler, Johanna Rockstroh, Brigitte Müller, Matthias M. 2011-03-25T09:26:17Z MEG gamma band activity in schizophrenia patients and healthy subjects in a mental arithmetic task and at rest Fehr, Thorsten eng Erschien zuerst in: Clinical Neurophysiology 111 (2000) 2079-2087 2000 Müller, Matthias M. Objectives: High frequency oscillations have been suggested as a correlate of cognitive processes and have recently also been implicated<br />in aberrant forms of information processing. The present study investigated whether magnetoencephalographic (MEG) gamma band activity<br />(20±71 Hz) can serve as an index of cognitive processes in the absence of external stimulation and to what extent gamma activity differs<br />between healthy people and schizophrenia patients.<br />Methods: The amount and topography of MEG power in the gamma band range was examined in 15 schizophrenia patients and 15 healthy<br />comparison subjects while performing a complex mental arithmetic task and at rest.<br />Results: In healthy subjects a left frontal and left fronto-temporal increase in gamma power was observed during mental arithmetic.<br />Schizophrenia patients either failed to display such a task effect (30±45 Hz) or had reversed lateralization with enhanced activity over right<br />frontal and right fronto-temporal regions under cognitive demands (45±71 Hz). In the frequency band from 60 to 71 Hz patients showed less<br />gamma at fronto-temporal, posterio-temporal and occipital sites irrespective of the task.<br />Conclusions: These results indicate, Ærst, that gamma topography can index cognitive activation in a very complex and purely internal<br />task. Second, groups differed in the pattern of activation during the task, a result which may be consistent with working memory dysfunction<br />in schizophrenia. Third, the general topographic difference between healthy subjects and patients is in line with the notion of abnormalities in<br />the thalamocortical circuit in schizophrenia. Elbert, Thomas application/pdf Kissler, Johanna

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