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Regulation of focal adhesion formation and filopodia extension by the cellular prion protein (PrPC)

Regulation of focal adhesion formation and filopodia extension by the cellular prion protein (PrPC)

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SCHROCK, Yvonne, Gonzalo SOLIS PADILLA, Claudia STÜRMER, 2009. Regulation of focal adhesion formation and filopodia extension by the cellular prion protein (PrPC). In: FEBS Letters. 583(2), pp. 389-393. ISSN 0014-5793. eISSN 1873-3468

@article{Schrock2009Regul-1119, title={Regulation of focal adhesion formation and filopodia extension by the cellular prion protein (PrPC)}, year={2009}, number={2}, volume={583}, issn={0014-5793}, journal={FEBS Letters}, pages={389--393}, author={Schrock, Yvonne and Solis Padilla, Gonzalo and Stürmer, Claudia} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/1119"> <dc:rights>deposit-license</dc:rights> <dc:creator>Stürmer, Claudia</dc:creator> <dc:contributor>Schrock, Yvonne</dc:contributor> <dc:creator>Schrock, Yvonne</dc:creator> <dc:creator>Solis Padilla, Gonzalo</dc:creator> <dcterms:abstract xml:lang="eng">While the prion protein (PrP) is clearly involved in neuropathology, its physiological roles remain elusive. Here, we demonstrate PrP functions in cell-substrate interaction in Drosophila S2, N2a and HeLa cells. PrP promotes cell spreading and/or filopodia formation when overexpressed, and lamellipodia when downregulated. Moreover, PrP normally accumulates in focal adhesions (FAs), and its downregulation leads to reduced FA numbers, increased FA length, along with Src and focal adhesion kinase (FAK) activation. Furthermore, its overexpression elicits the formation of novel FA-like structures, which require intact reggie/flotillin microdomains. Altogether, PrP modulates process formation and FA dynamics, possibly via signal transduction involving FAK and Src.</dcterms:abstract> <dc:contributor>Solis Padilla, Gonzalo</dc:contributor> <dc:language>eng</dc:language> <dcterms:issued>2009</dcterms:issued> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dcterms:bibliographicCitation>Publ. in: FEBS Letters 583 (2009), 2, pp. 389-393</dcterms:bibliographicCitation> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/1119"/> <dc:contributor>Stürmer, Claudia</dc:contributor> <dcterms:title>Regulation of focal adhesion formation and filopodia extension by the cellular prion protein (PrPC)</dcterms:title> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:06:16Z</dcterms:available> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:06:16Z</dc:date> </rdf:Description> </rdf:RDF>

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