Antiparallel Arrangement of the Helices of Vesicle-Bound alpha-Synuclein


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DRESCHER, Malte, Gertjan VELDHUIS, Bart D. van ROOIJEN, Sergey MILIKISYANTS, Vinod SUBRAMANIAM, Martina HUBER, 2008. Antiparallel Arrangement of the Helices of Vesicle-Bound alpha-Synuclein. In: Journal of the American Chemical Society. 130(25), pp. 7796-7797. ISSN 0002-7863. eISSN 1520-5126

@article{Drescher2008Antip-1110, title={Antiparallel Arrangement of the Helices of Vesicle-Bound alpha-Synuclein}, year={2008}, doi={10.1021/ja801594s}, number={25}, volume={130}, issn={0002-7863}, journal={Journal of the American Chemical Society}, pages={7796--7797}, author={Drescher, Malte and Veldhuis, Gertjan and Rooijen, Bart D. van and Milikisyants, Sergey and Subramaniam, Vinod and Huber, Martina} }

<rdf:RDF xmlns:rdf="" xmlns:bibo="" xmlns:dc="" xmlns:dcterms="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dc:creator>Drescher, Malte</dc:creator> <bibo:uri rdf:resource=""/> <dc:language>eng</dc:language> <dc:contributor>Huber, Martina</dc:contributor> <dc:contributor>Subramaniam, Vinod</dc:contributor> <dc:contributor>Rooijen, Bart D. van</dc:contributor> <dc:rights>deposit-license</dc:rights> <dcterms:bibliographicCitation>Publ. in: Journal of the American Chemical Society 130 (2008), 25, pp. 7796-7797</dcterms:bibliographicCitation> <dcterms:abstract xml:lang="eng">alpha-Synuclein (alpha S) is the main component of Lewy bodies from Parkinson's disease. That alpha S binds to membranes is known, but the conformation it adopts is still unclear. Pulsed EPR on doubly spin-labeled variants of alpha S sheds light on the most likely structure. For alpha S bound to vesicles large enough to accommodate also the extended conformation, an antiparallel helix conformation is found. This suggests that the bent structure shown is the preferred conformation of alpha S on membranes.</dcterms:abstract> <dc:creator>Huber, Martina</dc:creator> <dc:creator>Milikisyants, Sergey</dc:creator> <dc:contributor>Drescher, Malte</dc:contributor> <dcterms:issued>2008</dcterms:issued> <dc:date rdf:datatype="">2011-03-22T17:55:17Z</dc:date> <dc:creator>Rooijen, Bart D. van</dc:creator> <dcterms:available rdf:datatype="">2011-03-22T17:55:17Z</dcterms:available> <dc:creator>Veldhuis, Gertjan</dc:creator> <dcterms:title>Antiparallel Arrangement of the Helices of Vesicle-Bound alpha-Synuclein</dcterms:title> <dc:contributor>Veldhuis, Gertjan</dc:contributor> <dc:creator>Subramaniam, Vinod</dc:creator> <dc:contributor>Milikisyants, Sergey</dc:contributor> <dcterms:rights rdf:resource=""/> </rdf:Description> </rdf:RDF>

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