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Elektrophysiologische Indizes der Informationsverarbeitung bei Patienten im 'Vegetativ State' und 'Minimally Conscious State' : Auftretensmuster und klinischer Vorhersagewert

Elektrophysiologische Indizes der Informationsverarbeitung bei Patienten im 'Vegetativ State' und 'Minimally Conscious State' : Auftretensmuster und klinischer Vorhersagewert

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STEPPACHER, Inga, 2010. Elektrophysiologische Indizes der Informationsverarbeitung bei Patienten im 'Vegetativ State' und 'Minimally Conscious State' : Auftretensmuster und klinischer Vorhersagewert [Dissertation]. Konstanz: University of Konstanz

@phdthesis{Steppacher2010Elekt-10857, title={Elektrophysiologische Indizes der Informationsverarbeitung bei Patienten im 'Vegetativ State' und 'Minimally Conscious State' : Auftretensmuster und klinischer Vorhersagewert}, year={2010}, author={Steppacher, Inga}, address={Konstanz}, school={Universität Konstanz} }

In this study we examined the development of 92 patients in a vegetative state or a minimally conscious state. The patients were hospitalised between 1995 and 2005 in the Kliniken Schmieder, Allensbach. 53 of the patients had been in a vegetative state (VS) at the date of their initial examination, 39 had been in a minimally conscious state (MCS). In our research we focused on the existence and prognostic value of two so called late and therefore cognitive event related potentials (ERPs): the P300 and N400.<br />We recruited former patients for a follow-up study, 2 to 13 years after they were discharged from the rehab hospital. The patients that were still alive were visited and we measured their condition with the glasgow outcome scale . For the deceased patients we tried to elicit information about the patient s last condition from their relatives. Clinically we find that after the follow-up time (of 2 to 13 years) around 50% of the patients were deceased, 25% showed no progress and 25% of the patients' condition improved. We also find that patients with a traumatic cause did improve more often and to a better outcome than patients with a hypoxic cause. And we find that VS and MCS patients did not significantly differ in their ability to improve.<br />In case of the P300, we find that patients in MCS and VS did show this ERP. But it did not yield any prognostic value. Meaning the condition of patients showing a P300 did not improve more frequently than patients who did not show the component.<br />That picture is completely different in case of the N400 component. The N400 typically occurs as a result of semantic incongruity. Here we find a positive correlation between a detectable N400 and a later positive development of the patients. This correlation holds true for patients in a VS and a MCS.<br />The main finding of the study is that contrary to claims in past publications more patients in a VS are able to produce an N400. It will help to improve our understanding of information processing by patients with very limited consciousness.<br />Another important finding is that the N400 component can be used to predict the awakening from the vegetative state and the regaining of (rudimentary) communication abilities. Steppacher, Inga deposit-license deu application/pdf Electrophysiological indices of information processing of patients in the Vegetative State and Minimally Conscious State occurrence and predictive value Steppacher, Inga 2010 2011-03-25T09:23:15Z Elektrophysiologische Indizes der Informationsverarbeitung bei Patienten im 'Vegetativ State' und 'Minimally Conscious State' : Auftretensmuster und klinischer Vorhersagewert

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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