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Effect of khat chewing on periodontal pathogens in subgingival biofilm from chronic periodontitis patients

Effect of khat chewing on periodontal pathogens in subgingival biofilm from chronic periodontitis patients

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Prüfsumme: MD5:b7fbeff97a992463cf2ce5cc081c7e52

AL-HEBSHI, Nezar Noor, Ali Kaid AL-SHARABI, Hussein Mohammed SHUGA-ALDIN, Mohammed AL-HARONI, Ibrahim GHANDOUR, 2010. Effect of khat chewing on periodontal pathogens in subgingival biofilm from chronic periodontitis patients. In: Journal of Ethnopharmacology. 132(3), pp. 564-569

@article{Al-Hebshi2010Effec-10815, title={Effect of khat chewing on periodontal pathogens in subgingival biofilm from chronic periodontitis patients}, year={2010}, doi={10.1016/j.jep.2010.08.051}, number={3}, volume={132}, journal={Journal of Ethnopharmacology}, pages={564--569}, author={Al-Hebshi, Nezar Noor and Al-Sharabi, Ali Kaid and Shuga-Aldin, Hussein Mohammed and Al-Haroni, Mohammed and Ghandour, Ibrahim} }

Ghandour, Ibrahim 2010 Al-Sharabi, Ali Kaid First publ. in: Journal of Ethnopharmacology 132 (2010), 3. pp. 564-569 2011-03-25T09:22:53Z Al-Haroni, Mohammed Aims: Existing in vitro and in vivo data suggest that khat may have a favorable effect on periodontal microbiota. The purpose of this study was to assess the effect of khat chewing on major periodontal pathogens in subgingival plaque samples from subjects with chronic periodontitis.<br />Materials and methods: 40 subgingival plaque samples were obtained from periodontitis and healthy sites of 10 khat chewers (40 y median age) and 10 khat non-chewers (37.5 y median age) with chronic periodontitis. Absolute and relative counts of 6 periodontal pathogens were determined in each sample using highly sensitive and specific Taqman real-time PCR assays. Data were analyzed using an ordinal regression model.<br />Results: Significantly more total bacteria were detected in samples from the periodontitis sites of the khat chewers (OR = 20). Treponema denticola was present at significantly higher absolute counts at the healthy as well as periodontitis sites of the khat chewers (OR = 3.13 and 13, respectively). However, the khat chewers harbored significantly lower absolute counts of Porphyromonas gingivalis at the healthy sites<br />(OR = 0.07). Furthermore, khat chewing was significantly associated with lower relative counts of Porphyromonas gingivalis, fusobacterium ssp., prevotella ssp. and Parvimonas micra-like species in subgingival plaque samples from both healthy and periodontitis sites (OR = 0.11 0.33). Only Treponema denticola was found in higher relative counts at the healthy sites of the khat chewers (OR = 2.98).<br />Conclusions: Overall, there was a lower burden of pathogens in the khat chewers. Findings from the current study are suggestive of a potential prebiotic effect for khat on periodontal microbiota. eng Shuga-Aldin, Hussein Mohammed Al-Sharabi, Ali Kaid Ghandour, Ibrahim Al-Hebshi, Nezar Noor 2011-03-25T09:22:53Z deposit-license Al-Hebshi, Nezar Noor Effect of khat chewing on periodontal pathogens in subgingival biofilm from chronic periodontitis patients Al-Haroni, Mohammed application/pdf Shuga-Aldin, Hussein Mohammed

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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