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The Risk of Posttraumatic Stress Disorder After Trauma Depends on Traumatic Load and the Catechol-O-Methyltransferase Val158Met Polymorphism

The Risk of Posttraumatic Stress Disorder After Trauma Depends on Traumatic Load and the Catechol-O-Methyltransferase Val158Met Polymorphism

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Prüfsumme: MD5:74b35a7f0a78b9fb7c5e16298d206e16

KOLASSA, Iris, Stephan KOLASSA, Verena ERTL, Andreas PAPASSOTIROPOULOS, Dominique J.-F. de QUERVAIN, 2010. The Risk of Posttraumatic Stress Disorder After Trauma Depends on Traumatic Load and the Catechol-O-Methyltransferase Val158Met Polymorphism. In: Biological Psychiatry. 67(4), pp. 304-308

@article{Kolassa2010Postt-10635, title={The Risk of Posttraumatic Stress Disorder After Trauma Depends on Traumatic Load and the Catechol-O-Methyltransferase Val158Met Polymorphism}, year={2010}, doi={10.1016/j.biopsych.2009.10.009}, number={4}, volume={67}, journal={Biological Psychiatry}, pages={304--308}, author={Kolassa, Iris and Kolassa, Stephan and Ertl, Verena and Papassotiropoulos, Andreas and Quervain, Dominique J.-F. de} }

eng 2011-03-25T09:20:16Z deposit-license First publ. in: Biological Psychiatry ; 67 (2010), 4. - S. 304-308 Ertl, Verena Quervain, Dominique J.-F. de Quervain, Dominique J.-F. de Ertl, Verena Kolassa, Iris Papassotiropoulos, Andreas Background<br />The risk for posttraumatic stress disorder (PTSD) depends on the number of traumatic event types experienced in a dose response relationship, but genetic factors are known to also influence the risk of PTSD. The catechol-O-methyltransferase (COMT) Val158Met polymorphism has been found to affect fear extinction and might play a role in the etiology of anxiety disorders.<br />Methods<br />Traumatic load and lifetime and current diagnosis of PTSD and COMT genotype were assessed in a sample of 424 survivors of the Rwandan Genocide living in the Nakivale refugee camp in southwestern Uganda.<br />Results<br />Higher numbers of different lifetime traumatic event types led to a higher prevalence of lifetime PTSD in a dose response relationship. However, this effect was modulated by the COMT genotype: whereas Val allele carriers showed the typical dose response relationship, Met/Met homozygotes exhibited a high risk for PTSD independently of the severity of traumatic load.<br />Conclusions<br />The present findings indicate a gene environment interaction between the human COMT Val158Met polymorphism and the number of traumatic event types experienced in the risk of developing PTSD. 2011-03-25T09:20:16Z The Risk of Posttraumatic Stress Disorder After Trauma Depends on Traumatic Load and the Catechol-O-Methyltransferase Val158Met Polymorphism Kolassa, Stephan Papassotiropoulos, Andreas Kolassa, Stephan Kolassa, Iris application/pdf 2010

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Kolassa_etal_2010_BiologicalPsychiatry.pdf 309

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