KOPS - Das Institutionelle Repositorium der Universität Konstanz

The Risk of Posttraumatic Stress Disorder After Trauma Depends on Traumatic Load and the Catechol-O-Methyltransferase Val158Met Polymorphism

The Risk of Posttraumatic Stress Disorder After Trauma Depends on Traumatic Load and the Catechol-O-Methyltransferase Val158Met Polymorphism

Zitieren

Dateien zu dieser Ressource

Prüfsumme: MD5:74b35a7f0a78b9fb7c5e16298d206e16

KOLASSA, Iris, Stephan KOLASSA, Verena ERTL, Andreas PAPASSOTIROPOULOS, Dominique J.-F. de QUERVAIN, 2010. The Risk of Posttraumatic Stress Disorder After Trauma Depends on Traumatic Load and the Catechol-O-Methyltransferase Val158Met Polymorphism. In: Biological Psychiatry. 67(4), pp. 304-308. Available under: doi: 10.1016/j.biopsych.2009.10.009

@article{Kolassa2010Postt-10635, title={The Risk of Posttraumatic Stress Disorder After Trauma Depends on Traumatic Load and the Catechol-O-Methyltransferase Val158Met Polymorphism}, year={2010}, doi={10.1016/j.biopsych.2009.10.009}, number={4}, volume={67}, journal={Biological Psychiatry}, pages={304--308}, author={Kolassa, Iris and Kolassa, Stephan and Ertl, Verena and Papassotiropoulos, Andreas and Quervain, Dominique J.-F. de} }

eng 2011-03-25T09:20:16Z Ertl, Verena deposit-license First publ. in: Biological Psychiatry ; 67 (2010), 4. - S. 304-308 Quervain, Dominique J.-F. de Quervain, Dominique J.-F. de Ertl, Verena Kolassa, Iris Papassotiropoulos, Andreas 2011-03-25T09:20:16Z Background<br />The risk for posttraumatic stress disorder (PTSD) depends on the number of traumatic event types experienced in a dose response relationship, but genetic factors are known to also influence the risk of PTSD. The catechol-O-methyltransferase (COMT) Val158Met polymorphism has been found to affect fear extinction and might play a role in the etiology of anxiety disorders.<br />Methods<br />Traumatic load and lifetime and current diagnosis of PTSD and COMT genotype were assessed in a sample of 424 survivors of the Rwandan Genocide living in the Nakivale refugee camp in southwestern Uganda.<br />Results<br />Higher numbers of different lifetime traumatic event types led to a higher prevalence of lifetime PTSD in a dose response relationship. However, this effect was modulated by the COMT genotype: whereas Val allele carriers showed the typical dose response relationship, Met/Met homozygotes exhibited a high risk for PTSD independently of the severity of traumatic load.<br />Conclusions<br />The present findings indicate a gene environment interaction between the human COMT Val158Met polymorphism and the number of traumatic event types experienced in the risk of developing PTSD. The Risk of Posttraumatic Stress Disorder After Trauma Depends on Traumatic Load and the Catechol-O-Methyltransferase Val158Met Polymorphism Kolassa, Stephan Papassotiropoulos, Andreas Kolassa, Stephan Kolassa, Iris application/pdf 2010

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

Kolassa_etal_2010_BiologicalPsychiatry.pdf 329

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto