The Risk of Posttraumatic Stress Disorder After Trauma Depends on Traumatic Load and the Catechol-O-Methyltransferase Val158Met Polymorphism

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Kolassa_etal_2010_BiologicalPsychiatry.pdf
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2010
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Kolassa, Stephan
Papassotiropoulos, Andreas
Quervain, Dominique J.-F. de
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Stress and trauma-associated immunological changes and their implications on health
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Biological Psychiatry. 2010, 67(4), pp. 304-308. Available under: doi: 10.1016/j.biopsych.2009.10.009
Zusammenfassung

Background
The risk for posttraumatic stress disorder (PTSD) depends on the number of traumatic event types experienced in a dose response relationship, but genetic factors are known to also influence the risk of PTSD. The catechol-O-methyltransferase (COMT) Val158Met polymorphism has been found to affect fear extinction and might play a role in the etiology of anxiety disorders.
Methods
Traumatic load and lifetime and current diagnosis of PTSD and COMT genotype were assessed in a sample of 424 survivors of the Rwandan Genocide living in the Nakivale refugee camp in southwestern Uganda.
Results
Higher numbers of different lifetime traumatic event types led to a higher prevalence of lifetime PTSD in a dose response relationship. However, this effect was modulated by the COMT genotype: whereas Val allele carriers showed the typical dose response relationship, Met/Met homozygotes exhibited a high risk for PTSD independently of the severity of traumatic load.
Conclusions
The present findings indicate a gene environment interaction between the human COMT Val158Met polymorphism and the number of traumatic event types experienced in the risk of developing PTSD.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
150 Psychologie
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COMT polymorphism, genetic polymorphisms, post-traumatic stress disorder, refugees, risk
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ISO 690KOLASSA, Iris-Tatjana, Stephan KOLASSA, Verena ERTL, Andreas PAPASSOTIROPOULOS, Dominique J.-F. de QUERVAIN, 2010. The Risk of Posttraumatic Stress Disorder After Trauma Depends on Traumatic Load and the Catechol-O-Methyltransferase Val158Met Polymorphism. In: Biological Psychiatry. 2010, 67(4), pp. 304-308. Available under: doi: 10.1016/j.biopsych.2009.10.009
BibTex
@article{Kolassa2010Postt-10635,
  year={2010},
  doi={10.1016/j.biopsych.2009.10.009},
  title={The Risk of Posttraumatic Stress Disorder After Trauma Depends on Traumatic Load and the Catechol-O-Methyltransferase Val158Met Polymorphism},
  number={4},
  volume={67},
  journal={Biological Psychiatry},
  pages={304--308},
  author={Kolassa, Iris-Tatjana and Kolassa, Stephan and Ertl, Verena and Papassotiropoulos, Andreas and Quervain, Dominique J.-F. de}
}
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