Aufgrund von Vorbereitungen auf eine neue Version von KOPS, können kommenden Montag und Dienstag keine Publikationen eingereicht werden. (Due to preparations for a new version of KOPS, no publications can be submitted next Monday and Tuesday.)
Type of Publication: | Journal article |
URI (citable link): | http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-18891 |
Author: | Brockhaus, Anke; Lehnertz, Klaus; Wienbruch, Christian; Kowalik, Zbigniew J.; Burr, Wieland; Elbert, Thomas; Hoke, M.; Elger, Christian E. |
Year of publication: | 1997 |
Published in: | Electroencephalography and clinical Neuropsychology ; 102 (1997). - pp. 423-436 |
DOI (citable link): | https://dx.doi.org/10.1016/S0921-884X(97)96625-X |
Summary: |
The usefulness of MEG-based techniques in lateralizing and localizing the epileptogenic area was investigated in the present study. Spontaneous and methohexital-induced spikes were studied in a group of 15 patients with temporomesial epilepsy using a 37-channel neuromagnetometer. The accuracy of the magnetic source imaging was compared to the results of electrocorticographic (ECoG) recordings. Differences of drug-induced spike densities in the MEG recordings between both sides confirmed a similar lateralizing power of the MEG and ECoG recordings. Source location analyses based on a moving dipole model resp. a rotating dipole model were performed using a spherical head model. After subdivision of the volume of each patient's head, 8 qcm cubicles containing at least 3 source locations were projected onto the individual MRI scan and resulted in source locations within or close to the presurgically defined primary epileptogenic area only in 3 of the 15 patients. Spike induction by methohexital has the advantage of shortening the recording period as compared to recordings of interictal epileptiform discharges. However, the correlation analyses of spike densities from MEG and ECoG recordings and the source location analyses from MEG recordings indicate that spikes generated in deep temporomesial structures may escape the MEG registration.
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Subject (DDC): | 150 Psychology |
Controlled Keywords (GND): | Magnetoenzephalographie, Temporallappen-Epilepsie, Methohexital |
Keywords: | Magnetoencephalography, Electrocorticography, Temporal lobe epilepsy, Source localization, Methohexital |
Link to License: | In Copyright |
BROCKHAUS, Anke, Klaus LEHNERTZ, Christian WIENBRUCH, Zbigniew J. KOWALIK, Wieland BURR, Thomas ELBERT, M. HOKE, Christian E. ELGER, 1997. Possibilities and limitations of magnetic source imaging of methohexital-induced epileptiform patterns in temporal lobe epilepsy patients. In: Electroencephalography and clinical Neuropsychology. 102, pp. 423-436. Available under: doi: 10.1016/S0921-884X(97)96625-X
@article{Brockhaus1997Possi-10614, title={Possibilities and limitations of magnetic source imaging of methohexital-induced epileptiform patterns in temporal lobe epilepsy patients}, year={1997}, doi={10.1016/S0921-884X(97)96625-X}, volume={102}, journal={Electroencephalography and clinical Neuropsychology}, pages={423--436}, author={Brockhaus, Anke and Lehnertz, Klaus and Wienbruch, Christian and Kowalik, Zbigniew J. and Burr, Wieland and Elbert, Thomas and Hoke, M. and Elger, Christian E.} }
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