Artificial ribozyme switches containing natural riboswitch aptamer domains

Wieland, Markus; Benz, Armin; Klauser, Benedikt; Hartig, Jörg S.

Artificial ribozyme switches containing natural riboswitch aptamer domains

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Datum

2009

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Angewandte Chemie International Edition. 2009, 48(15), pp. 2715-2718. eISSN 1433-7851. Available under: doi: 10.1002/anie.200805311

Zusammenfassung

RNA Lego: The use of natural riboswitch aptamers in synthetic RNA switches (see picture) should broaden the scope of artificial RNA regulators dramatically. It is shown that thiamine pyrophosphate (TPP) aptamers can be used in engineered devices as very sensitive switches of gene expression in unmodified organisms. The approach demonstrates that intrinsic metabolites can be utilized as external effectors of cellular functions.

Fachgebiet (DDC)

540 Chemie

Zitieren

ISO 690

WIELAND, Markus, Armin BENZ, Benedikt KLAUSER, Jörg S. HARTIG, 2009. Artificial ribozyme switches containing natural riboswitch aptamer domains. In: Angewandte Chemie International Edition. 2009, 48(15), pp. 2715-2718. eISSN 1433-7851. Available under: doi: 10.1002/anie.200805311

BibTex

@article{Wieland2009Artif-1039,
  year={2009},
  doi={10.1002/anie.200805311},
  title={Artificial ribozyme switches containing natural riboswitch aptamer domains},
  number={15},
  volume={48},
  journal={Angewandte Chemie International Edition},
  pages={2715--2718},
  author={Wieland, Markus and Benz, Armin and Klauser, Benedikt and Hartig, Jörg S.}
}

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Universitätsbibliographie

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