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Source Distribution of Neuromagnetic Slow Waves and MEG-Delta Activity in Schizophrenic Patients

Source Distribution of Neuromagnetic Slow Waves and MEG-Delta Activity in Schizophrenic Patients

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Prüfsumme: MD5:ab112e05229ba0b8d6c940b3b375dc37

FEHR, Thorsten, Johanna KISSLER, Stephan MORATTI, Christian WIENBRUCH, Brigitte ROCKSTROH, Thomas ELBERT, 2001. Source Distribution of Neuromagnetic Slow Waves and MEG-Delta Activity in Schizophrenic Patients. In: Biological psychiatry. 50, pp. 108-116

@article{Fehr2001Sourc-10332, title={Source Distribution of Neuromagnetic Slow Waves and MEG-Delta Activity in Schizophrenic Patients}, year={2001}, doi={10.1016/S0006-3223(01)01122-2}, volume={50}, journal={Biological psychiatry}, pages={108--116}, author={Fehr, Thorsten and Kissler, Johanna and Moratti, Stephan and Wienbruch, Christian and Rockstroh, Brigitte and Elbert, Thomas} }

Wienbruch, Christian 2011-03-25T09:16:06Z Biological psychiatry ; 50 (2001). - S. 108-116 Fehr, Thorsten Rockstroh, Brigitte 2001 application/pdf eng Elbert, Thomas Kissler, Johanna Background: Schizophrenic patients exhibit more activity<br />in the electroencephalographic delta and theta frequency<br />range than do control subjects. Using magnetic source<br />imaging (MSI) our study aimed to explore this phenomenon<br />in the magnetoencephalogram (MEG), the distribution<br />of its sources, and associations between symptom<br />profiles and sources of low-frequency activity in the brain.<br />Methods: Whole-head MEG recordings were obtained<br />from 28 schizophrenic patients and 20 healthy control<br />subjects during a resting condition. The generators of the<br />focal magnetic slow waves were located employing a<br />single moving dipole model. Distributed or multiple delta<br />and theta sources were captured by the minimum norm<br />estimate.<br />Results: Both localization procedures showed slow wave<br />activity to be enhanced in schizophrenic patients compared<br />with control subjects. Focal slow wave activity<br />differed most between groups in frontotemporal and in<br />posterior regions. Slow wave activity was associated with<br />symptom characteristics in that positive symptoms varied<br />with frontal delta and theta activity.<br />Conclusions: Results indicate that activity in low-frequency<br />bands in schizophrenic patients exceeds the activity<br />of control subjects in distinct areas, and that this focal<br />clustering of neuromagnetic slow waves may be related to psychopathologic characteristics. Elbert, Thomas Fehr, Thorsten Moratti, Stephan Kissler, Johanna Rockstroh, Brigitte Wienbruch, Christian 2011-03-25T09:16:06Z Moratti, Stephan Source Distribution of Neuromagnetic Slow Waves and MEG-Delta Activity in Schizophrenic Patients deposit-license

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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