Type of Publication: | Journal article |
URI (citable link): | http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-14185 |
Author: | Fehr, Thorsten; Kissler, Johanna; Moratti, Stephan; Wienbruch, Christian; Rockstroh, Brigitte; Elbert, Thomas |
Year of publication: | 2001 |
Published in: | Biological psychiatry ; 50 (2001). - pp. 108-116 |
DOI (citable link): | https://dx.doi.org/10.1016/S0006-3223(01)01122-2 |
Summary: |
Background: Schizophrenic patients exhibit more activity
in the electroencephalographic delta and theta frequency range than do control subjects. Using magnetic source imaging (MSI) our study aimed to explore this phenomenon in the magnetoencephalogram (MEG), the distribution of its sources, and associations between symptom profiles and sources of low-frequency activity in the brain. Methods: Whole-head MEG recordings were obtained from 28 schizophrenic patients and 20 healthy control subjects during a resting condition. The generators of the focal magnetic slow waves were located employing a single moving dipole model. Distributed or multiple delta and theta sources were captured by the minimum norm estimate. Results: Both localization procedures showed slow wave activity to be enhanced in schizophrenic patients compared with control subjects. Focal slow wave activity differed most between groups in frontotemporal and in posterior regions. Slow wave activity was associated with symptom characteristics in that positive symptoms varied with frontal delta and theta activity. Conclusions: Results indicate that activity in low-frequency bands in schizophrenic patients exceeds the activity of control subjects in distinct areas, and that this focal clustering of neuromagnetic slow waves may be related to psychopathologic characteristics. |
Subject (DDC): | 150 Psychology |
Keywords: | Schizophrenia, magnetoencephalography, slow waves, delta, theta, dipole modeling |
Link to License: | In Copyright |
FEHR, Thorsten, Johanna KISSLER, Stephan MORATTI, Christian WIENBRUCH, Brigitte ROCKSTROH, Thomas ELBERT, 2001. Source Distribution of Neuromagnetic Slow Waves and MEG-Delta Activity in Schizophrenic Patients. In: Biological psychiatry. 50, pp. 108-116. Available under: doi: 10.1016/S0006-3223(01)01122-2
@article{Fehr2001Sourc-10332, title={Source Distribution of Neuromagnetic Slow Waves and MEG-Delta Activity in Schizophrenic Patients}, year={2001}, doi={10.1016/S0006-3223(01)01122-2}, volume={50}, journal={Biological psychiatry}, pages={108--116}, author={Fehr, Thorsten and Kissler, Johanna and Moratti, Stephan and Wienbruch, Christian and Rockstroh, Brigitte and Elbert, Thomas} }
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