Early life stress and psychiatric disorder modulatecortical responses to affective stimuli

Altered affective processing has been proposed as mediating between early life stress (ELS) and subsequent psychopathology. The present study examined whether ELS influences affective cortical processing differently in psychiatric patients and healthy subjects. The number of stressful experiences before onset of puberty was assessed in 50 inpatients with diagnoses ofMajor Depressive Disorder, schizophrenia, drug addiction, or Borderline Personality Disorder and in 20 healthy comparison subjects. Subjects monitored pleasant, neutral, and unpleasant pictures during magnetoencephalographic recording. Suppression of right-posterior activity 160 210 ms after stimulus onset was associated with certain diagnoses and high ELS. Results confirmed specific contributions of ELS versus adult stress, comorbid posttraumatic stress disorder, or depression.

Subject (DDC)

150 Psychology

Keywords

Early life stress,Psychopathology,Affective modulation,IAPS,MEG,childhood stress

Cite This

ISO 690

WEBER, Katja, Gregory A. MILLER, Harald T. SCHUPP, Jens BORGELT, Barbara AWISZUS, Tzvetan G. POPOV, Thomas ELBERT, Brigitte ROCKSTROH, 2009. Early life stress and psychiatric disorder modulatecortical responses to affective stimuli. In: Psychophysiology. 46(6), pp. 1234-1243. Available under: doi: 10.1111/j.1469-8986.2009.00871.x

BibTex

@article{Weber2009Early-10275,
  year={2009},
  doi={10.1111/j.1469-8986.2009.00871.x},
  title={Early life stress and psychiatric disorder modulatecortical responses to affective stimuli},
  number={6},
  volume={46},
  journal={Psychophysiology},
  pages={1234--1243},
  author={Weber, Katja and Miller, Gregory A. and Schupp, Harald T. and Borgelt, Jens and Awiszus, Barbara and Popov, Tzvetan G. and Elbert, Thomas and Rockstroh, Brigitte}
}

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Bibliography of Konstanz

Yes