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Tinnitus perception and distress is related to abnormal spontaneous brain activity as measured by magnetoencephalography

Tinnitus perception and distress is related to abnormal spontaneous brain activity as measured by magnetoencephalography

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Prüfsumme: MD5:e5c50020bcd6db6bc391442803070e30

WEISZ, Nathan, Stephan MORATTI, Marcus MEINZER, Katalin DOHRMANN, Thomas ELBERT, 2005. Tinnitus perception and distress is related to abnormal spontaneous brain activity as measured by magnetoencephalography. In: PLoS Medicine. 2(6), e153. Available under: doi: 10.1371/journal.pmed.0020153

@article{Weisz2005Tinni-10261, title={Tinnitus perception and distress is related to abnormal spontaneous brain activity as measured by magnetoencephalography}, year={2005}, doi={10.1371/journal.pmed.0020153}, number={6}, volume={2}, journal={PLoS Medicine}, author={Weisz, Nathan and Moratti, Stephan and Meinzer, Marcus and Dohrmann, Katalin and Elbert, Thomas}, note={Article Number: e153} }

Background: The neurophysiological mechanisms underlying tinnitus perception are not well understood. Surprisingly, there have been no group studies comparing abnormalities in the ongoing, spontaneous neuronal activity in individuals with and without tinnitus perception.<br />Methods and Findings: Here, we show that the spontaneous neuronal activity of a group of individuals with tinnitus (n = 17) is characterised by a marked reduction in alpha (8 12 Hz) power together with an enhancement in delta (1.5 4 Hz) as compared to a normal hearing control group (n = 16). This pattern was especially pronounced for temporal regions. Moreover, correlations with tinnitusrelated distress revealed strong associations with this abnormal spontaneous activity pattern, particularly in right temporal and left frontal areas. Overall, effects were stronger for the alpha than for the delta frequency band. A data stream of 5 min, recorded with a whole-head neuromagnetometer under a resting condition, was sufficient to extract the marked differences.<br />Conclusions: Despite some limitations, there are arguments that the regional pattern of abnormal spontaneous activity we found could reflect a tinnitus-related cortical network. This finding, which suggests that a neurofeedback approach could reduce the adverse effects of this disturbing condition, could have important implications for the treatment of tinnitus. deposit-license 2005 Elbert, Thomas eng Elbert, Thomas Weisz, Nathan Weisz, Nathan First publ. in: PLoS Medicine ; 2 (2005), 6. - e153 2011-03-25T09:15:32Z Dohrmann, Katalin 2011-03-25T09:15:32Z Tinnitus perception and distress is related to abnormal spontaneous brain activity as measured by magnetoencephalography Meinzer, Marcus Meinzer, Marcus Dohrmann, Katalin Moratti, Stephan Moratti, Stephan application/pdf

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