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Disordered semantic representation in schizophrenic temporal cortex revealed by neuromagnetic response patterns

Disordered semantic representation in schizophrenic temporal cortex revealed by neuromagnetic response patterns

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LÖW, Andreas, Brigitte ROCKSTROH, Thomas ELBERT, Yaron SILBERMAN, Shlomo BENTIN, 2006. Disordered semantic representation in schizophrenic temporal cortex revealed by neuromagnetic response patterns. In: BMC Psychiatry. 6(23). Available under: doi: 10.1186/1471-244X-6-23

@article{Low2006Disor-10187, title={Disordered semantic representation in schizophrenic temporal cortex revealed by neuromagnetic response patterns}, year={2006}, doi={10.1186/1471-244X-6-23}, number={23}, volume={6}, journal={BMC Psychiatry}, author={Löw, Andreas and Rockstroh, Brigitte and Elbert, Thomas and Silberman, Yaron and Bentin, Shlomo} }

Löw, Andreas Löw, Andreas Background: Loosening of associations and thought disruption are key features of schizophrenic psychopathology. Alterations in neural networks underlying this basic abnormality have not yet been sufficiently identified. Previously, we demonstrated that spatio-temporal clustering of magnetic brain responses to pictorial stimuli map categorical representations in temporal cortex. This result has opened the possibility to quantify associative strength within and across semantic categories in schizophrenic patients. We hypothesized that in contrast to controls, schizophrenic patients exhibit disordered representations of semantic categories.<br />Methods: The spatio-temporal clusters of brain magnetic activities elicited by object pictures related to super-ordinate (flowers, animals, furniture, clothes) and base-level (e.g. tulip, rose, orchid, sunflower) categories were analysed in the source space for the time epochs 170-210 and 210-450 ms following stimulus onset and were compared between 10 schizophrenic patients and 10 control subjects.<br />Results: Spatio-temporal correlations of responses elicited by base-level concepts and the difference of within vs. across super-ordinate categories were distinctly lower in patients than in controls. Additionally, in contrast to the well-defined categorical representation in control subjects, unsupervised clustering indicated poorly defined representation of semantic categories in patients. Within the patient group, distinctiveness of categorical representation in the temporal cortex was positively related to negative symptoms and tended to be inversely related to positive symptoms.<br />Conclusion: Schizophrenic patients show a less organized representation of semantic categories in clusters of magnetic brain responses than healthy adults. This atypical neural network architecture may be a correlate of loosening of associations, promoting positive symptoms. deposit-license 2011-03-25T09:14:55Z First publ. in: BMC Psychiatry 2006, 6:23 Elbert, Thomas Elbert, Thomas application/pdf Rockstroh, Brigitte Silberman, Yaron eng Silberman, Yaron Bentin, Shlomo Disordered semantic representation in schizophrenic temporal cortex revealed by neuromagnetic response patterns Bentin, Shlomo 2011-03-25T09:14:55Z Rockstroh, Brigitte 2006

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