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Neuromagnetische Korrelate der Sprachverarbeitung bei Patienten mit chronischer Aphasie

Neuromagnetische Korrelate der Sprachverarbeitung bei Patienten mit chronischer Aphasie

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DJUNDJA, Daniela, 2009. Neuromagnetische Korrelate der Sprachverarbeitung bei Patienten mit chronischer Aphasie

@phdthesis{Djundja2009Neuro-10080, title={Neuromagnetische Korrelate der Sprachverarbeitung bei Patienten mit chronischer Aphasie}, year={2009}, author={Djundja, Daniela}, address={Konstanz}, school={Universität Konstanz} }

2009 2011-03-25T09:13:57Z application/pdf Djundja, Daniela The present study examined language processing in patients with chronic aphasia before and after intensive language therapy (either Constrained Induced Aphasia Therapy, Meinzer et al., 2001; or Model-Orientated Aphasia Therapy, Barthel, 2005). The findings were compared with those of healty controls surveyed two times at an interval of two weeks. Using the psychophysiological method of magnetoencephalography (MEG), two complex linguistic phenomenons have been investigated: word class processing and representation and processing of verbs of different argument structure (Assadollahi und Rockstroh, 2008). The aim of this study was to get further insights in the mechanisms of recovery from aphasia.<br />Processing of different word classes (content-, function- and pseudowords) was exaimed in the first experiment. Stimuli were presented either alternating or randomly. Compared to healthy controls patients showed lefthemispheric hyperactivity independend of word class or condition. Before language therapy evidence for word class processing was found in the alternating condition only. After language therapy evidence for word class processing was found in both conditions. The overall activity changes indicate two recovery mechanisms: reactivation and more efficient use of language associated areas.<br />The second experiment examined the processing of isolated verbs of different argument structure and of those verbs presented in minimal context. In healthy controls verbs of different argument structure (isolated and with minimal context) evoked different activation in left language areas. Before language therapy isolated verbs evoked a compareable pattern in contralateral right areas in patients. After language therapy the pattern was no longer found in the right hemisphere but in the left hemisphere. Verbs embedded into sentences did not evoke compareable cortical response patterns in patients at all.<br />The results might reflect reorganisation of language network after intensive language therapy. Both experiments emphasize the relevance of two mechanisms of recovery: a more efficient utilization of the existing language network and reactivation of perilesional areas in the left hemisphere. 2011-03-25T09:13:57Z Neuromagnetische Korrelate der Sprachverarbeitung bei Patienten mit chronischer Aphasie deposit-license deu Djundja, Daniela Neuromagnetic Correlates of language processing in patients with chronic aphasia

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