Synthesis of (3S)-Hydroxyandrosta-5,7-diene-17-ones via Intramolecular Cobalt-Mediated [2+2+2] Cycloaddition
| Type of Publication: | Journal article |
| URI (citable link): | http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-46214 |
| Author: | Groth, Ulrich; Richter, Norbert; Kalogerakis, Aris |
| Year of publication: | 2006 |
| Published in: | Synlett ; 2006 (2006), 6. - pp. 905-908. - ISSN 0936-5214. - eISSN 1437-2096 |
| DOI (citable link): | https://dx.doi.org/10.1055/s-2006-939064 |
| Summary: |
A new method for the synthesis of lumisterin-type steroids following the D→ABCD approach is reported. A key step is the cobalt-induced cyclization of a cyclopentanoid enediyne, which was prepared via thioalkylation of the zinc enolate of a 2,3-substituted cyclopentanone with α-chlorosulfides.
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| Subject (DDC): | 540 Chemistry |
| Keywords: | cobalt, cycloaddition, cyclopentanones, steroids, vitamins |
| Link to License: | Attribution-NonCommercial-NoDerivs 2.0 Generic |
| Bibliography of Konstanz: | Yes |
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GROTH, Ulrich, Norbert RICHTER, Aris KALOGERAKIS, 2006. Synthesis of (3S)-Hydroxyandrosta-5,7-diene-17-ones via Intramolecular Cobalt-Mediated [2+2+2] Cycloaddition. In: Synlett. 2006(6), pp. 905-908. ISSN 0936-5214. eISSN 1437-2096. Available under: doi: 10.1055/s-2006-939064
@article{Groth2006Synth-10068, title={Synthesis of (3S)-Hydroxyandrosta-5,7-diene-17-ones via Intramolecular Cobalt-Mediated [2+2+2] Cycloaddition}, year={2006}, doi={10.1055/s-2006-939064}, number={6}, volume={2006}, issn={0936-5214}, journal={Synlett}, pages={905--908}, author={Groth, Ulrich and Richter, Norbert and Kalogerakis, Aris} }
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