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Disparate evolution of prion protein domains and the distinct origin of Doppel- and prion-related loci revealed by fish-to-mammal comparisons

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111_Duplicated_prion_proteins_in_fish.pdf
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2006

Autor:innen

Rivera-Milla, Eric
Oidtmann, Birgit
Panagiotidis, Cynthia
Baier, Michael
Sklaviadis, Theodoros
Hoffmann, Rudolf
Zhou, Yi

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FASEB Journal. 2006, 20(2), pp. 317-319. eISSN 1530-6860. Available under: doi: 10.1096/fj.05-4279fje

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Our current understanding of prion biology and disease is largely based on studies performed on mammals, yet basic questions about the physiological function of prion proteins (PrPs) and the molecular nature of prion disorders remain elusive. To facilitate the establishment of non-mammalian models for prion research, we characterized the sequence, structural, and genomic homology between fish and other vertebrate PrPs, and analyzed the distinct molecular mechanisms that shaped the evolution of vertebrate PrP domains.

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570 Biowissenschaften, Biologie

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ISO 690RIVERA-MILLA, Eric, Birgit OIDTMANN, Cynthia PANAGIOTIDIS, Michael BAIER, Theodoros SKLAVIADIS, Rudolf HOFFMANN, Yi ZHOU, Gonzalo SOLIS PADILLA, Claudia STÜRMER, Edward MÁLAGA-TRILLO, 2006. Disparate evolution of prion protein domains and the distinct origin of Doppel- and prion-related loci revealed by fish-to-mammal comparisons. In: FASEB Journal. 2006, 20(2), pp. 317-319. eISSN 1530-6860. Available under: doi: 10.1096/fj.05-4279fje
BibTex
@article{RiveraMilla2006Dispa-6739,
  year={2006},
  doi={10.1096/fj.05-4279fje},
  title={Disparate evolution of prion protein domains and the distinct origin of Doppel- and prion-related loci revealed by fish-to-mammal comparisons},
  number={2},
  volume={20},
  journal={FASEB Journal},
  pages={317--319},
  author={Rivera-Milla, Eric and Oidtmann, Birgit and Panagiotidis, Cynthia and Baier, Michael and Sklaviadis, Theodoros and Hoffmann, Rudolf and Zhou, Yi and Solis Padilla, Gonzalo and Stürmer, Claudia and Málaga-Trillo, Edward}
}
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