Publikation:

Epigenetic "Drivers" of Cancer

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2021

Autor:innen

Melino, Gerry

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URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-2-var5c5zlred1
DOI (zitierfähiger Link)
https://doi.org/10.1016/j.jmb.2021.167094
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CC BY 4.0

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Open Access-Veröffentlichung
Open Access Hybrid

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Biologie: Publikationen
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Published

Erschienen in

Journal of molecular biology. Elsevier. 2021, 433(15), 167094. ISSN 0022-2836. eISSN 1089-8638. Available under: doi: 10.1016/j.jmb.2021.167094

Zusammenfassung

Genetics is at the basis of cancer initiation and evolution, but emerging evidence indicates that mutations are not sufficient to produce cancer, indicating a role for epigenetic contributions to the different stages of tumorigenesis. While the genetic tracks of cancer have been widely investigated, the epigenetic "drivers" remain a vague definition. Gene-environment interactions can produce gene-regulatory programs that dictate pathogenesis; this implies a reciprocal relationship where environmental factors contribute to genetic mechanisms of tumorigenesis (i.e. mutagenesis) and genetic factors influence the cellular response to extrinsic stress. In this review article, we attempt to summarise the most remarkable findings demonstrating a contribution of epigenetic factors as proper "drivers" of tumorigenesis. We also try to pose attention on the relevance of epigenetic mechanisms as downstream consequences of genes versus environment interaction.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

cancer epigenetics, transcriptional rewiring, gene-environment interaction, cancer, cancer genetics

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ISO 690BUTERA, Alessio, Gerry MELINO, Ivano AMELIO, 2021. Epigenetic "Drivers" of Cancer. In: Journal of molecular biology. Elsevier. 2021, 433(15), 167094. ISSN 0022-2836. eISSN 1089-8638. Available under: doi: 10.1016/j.jmb.2021.167094
BibTex
@article{Butera2021Epige-56538,
  year={2021},
  doi={10.1016/j.jmb.2021.167094},
  title={Epigenetic "Drivers" of Cancer},
  number={15},
  volume={433},
  issn={0022-2836},
  journal={Journal of molecular biology},
  author={Butera, Alessio and Melino, Gerry and Amelio, Ivano},
  note={Article Number: 167094}
}
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