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Losing control : Prefrontal emotion regulation relates to symptom severity and predicts treatment-related symptom change in adolescent girls with conduct disorder

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2025

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Raschle, Nora Maria
Borbás, Réka
Dimanova, Plamina
Kohls, Gregor
De Brito, Stephane
Fairchild, Graeme
Freitag, Christine M.
Konrad, Kerstin
Stadler, Christina

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Swiss National Science Foundation: 105314_207624
European Union (EU): 602407

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Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. Elsevier. 2025, 10(1), S. 80-93. ISSN 2451-9022. Verfügbar unter: doi: 10.1016/j.bpsc.2024.08.005

Zusammenfassung

Background: Emotion regulation skills are linked to corticolimbic brain activity (e.g., dorsolateral prefrontal cortex (dlPFC) and limbic regions) and enable an individual to control their emotional experiences thus allowing healthy social functioning. Disruptions in emotion regulation skills are reported in neuropsychiatric disorders, including conduct disorder or oppositional defiant disorder (CD/ODD). Clinically recognized means to ameliorate emotion regulation deficits observed in CD/ODD include cognitive or dialectical behavioral skills therapy as implemented in the START-NOW program. However, the role of emotion regulation and its neural substrates in symptom severity and prognosis following treatment of adolescent CD/ODD has yet to be investigated.

Methods: Cross-sectional data including fMRI responses during emotion regulation (N=114; average age=15years), repeated-measures assessments of symptom severity (pre-, post-treatment, long-term follow-up), and fMRI data collected prior to and following the START-NOW randomized controlled trial (n=44) for female adolescents with CD/ODD were analyzed using group comparisons and multiple regression.

Results: First, behavioral and neural correlates of emotion regulation are disrupted in female adolescents with CD/ODD. Second, ODD symptom severity is negatively associated with dlPFC/precentral gyrus activity during regulation. Third, treatment-related symptom changes are predicted by pre-treatment ODD symptom severity and regulatory dlPFC/precentral activity. Additionally, pre-treatment dlPFC/precentral activity and ODD symptom severity predict long-term reductions in symptom severity following treatment for those participants that received the START NOW treatment.

Conclusion: Our findings demonstrate the important role that emotion regulation skills play in the characteristics of CD/ODD and show that regulatory dlPFC/precentral activity is positively associated with treatment response in female adolescents with CD/ODD.

Zusammenfassung in einer weiteren Sprache

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150 Psychologie

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emotion regulation, brain development, conduct disorder, oppositional defiant disorder, randomized controlled trial, fMRI

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ISO 690RASCHLE, Nora Maria, Réka BORBÁS, Plamina DIMANOVA, Eva UNTERNAEHRER, Gregor KOHLS, Stephane DE BRITO, Graeme FAIRCHILD, Christine M. FREITAG, Kerstin KONRAD, Christina STADLER, 2025. Losing control : Prefrontal emotion regulation relates to symptom severity and predicts treatment-related symptom change in adolescent girls with conduct disorder. In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. Elsevier. 2025, 10(1), S. 80-93. ISSN 2451-9022. Verfügbar unter: doi: 10.1016/j.bpsc.2024.08.005
BibTex
@article{Raschle2025-01Losin-70705,
  title={Losing control : Prefrontal emotion regulation relates to symptom severity and predicts treatment-related symptom change in adolescent girls with conduct disorder},
  year={2025},
  doi={10.1016/j.bpsc.2024.08.005},
  number={1},
  volume={10},
  issn={2451-9022},
  journal={Biological Psychiatry: Cognitive Neuroscience and Neuroimaging},
  pages={80--93},
  author={Raschle, Nora Maria and Borbás, Réka and Dimanova, Plamina and Unternaehrer, Eva and Kohls, Gregor and De Brito, Stephane and Fairchild, Graeme and Freitag, Christine M. and Konrad, Kerstin and Stadler, Christina}
}
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