Publikation: Isolation of cDNA encoding full-length rat (Rattus norvegicus) poly(ADP-ribose) polymerase
Dateien
Datum
Autor:innen
Herausgeber:innen
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
DOI (zitierfähiger Link)
Internationale Patentnummer
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Sammlungen
Core Facility der Universität Konstanz
Titel in einer weiteren Sprache
Publikationstyp
Publikationsstatus
Erschienen in
Zusammenfassung
Poly(ADP-ribose) polymerase (EC 2.4.2.30) is a nuclear enzyme which binds to DNA breaks and then catalyzes the covalent modification of acceptor proteins with poly(ADP-ribose). Poly(ADP-ribose) polymerase activity contributes to the recovery of proliferating cells from DNA damage and to the maintenance of genomic stability, which may be mediated by effects on chromatin structure, DNA base-excision repair and cell cycle regulation. We established the complete cDNA sequence of rat poly(ADP-ribose) polymerase by RT-PCR and direct sequencing of amplification products and compared it with that of other mammalian species. The amino acid sequence homology is strikingly high. The best conserved regions are the known functional modules of poly(ADP-ribose) polymerase.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
Schlagwörter
Konferenz
Rezension
Zitieren
ISO 690
BENEKE, Sascha, Ralph MEYER, Alexander BÜRKLE, 1997. Isolation of cDNA encoding full-length rat (Rattus norvegicus) poly(ADP-ribose) polymerase. In: Biochemistry and Molecular Biology International. Wiley-Blackwell. 1997, 43(4), pp. 755-761. ISSN 1039-9712. eISSN 1521-6551. Available under: doi: 10.1080/15216549700204571BibTex
@article{Beneke1997-11Isola-52449, year={1997}, doi={10.1080/15216549700204571}, title={Isolation of cDNA encoding full-length rat (Rattus norvegicus) poly(ADP-ribose) polymerase}, number={4}, volume={43}, issn={1039-9712}, journal={Biochemistry and Molecular Biology International}, pages={755--761}, author={Beneke, Sascha and Meyer, Ralph and Bürkle, Alexander} }
RDF
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/52449"> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/52449"/> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <dc:contributor>Bürkle, Alexander</dc:contributor> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dc:language>eng</dc:language> <dcterms:abstract xml:lang="eng">Poly(ADP-ribose) polymerase (EC 2.4.2.30) is a nuclear enzyme which binds to DNA breaks and then catalyzes the covalent modification of acceptor proteins with poly(ADP-ribose). Poly(ADP-ribose) polymerase activity contributes to the recovery of proliferating cells from DNA damage and to the maintenance of genomic stability, which may be mediated by effects on chromatin structure, DNA base-excision repair and cell cycle regulation. We established the complete cDNA sequence of rat poly(ADP-ribose) polymerase by RT-PCR and direct sequencing of amplification products and compared it with that of other mammalian species. The amino acid sequence homology is strikingly high. The best conserved regions are the known functional modules of poly(ADP-ribose) polymerase.</dcterms:abstract> <dc:creator>Meyer, Ralph</dc:creator> <dc:creator>Bürkle, Alexander</dc:creator> <dcterms:issued>1997-11</dcterms:issued> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <foaf:homepage rdf:resource="http://localhost:8080/"/> <dcterms:title>Isolation of cDNA encoding full-length rat (Rattus norvegicus) poly(ADP-ribose) polymerase</dcterms:title> <dc:rights>terms-of-use</dc:rights> <dc:creator>Beneke, Sascha</dc:creator> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Beneke, Sascha</dc:contributor> <dc:contributor>Meyer, Ralph</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-01-15T09:02:27Z</dcterms:available> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-01-15T09:02:27Z</dc:date> </rdf:Description> </rdf:RDF>