An artificial PAP gene breaks self-tolerance and promotes tumor regression in the TRAMP model for prostate carcinoma

Kurzanzeige
dc.contributor.authorSpies, Elmar
dc.contributor.authorReichardt, Wilfrieddeu
dc.contributor.authorAlvarez Salinas, Gerardo Omar
dc.contributor.authorGroettrup, Marcus
dc.contributor.authorÖhlschläger, Peter
dc.date.accessioned2012-04-04T13:38:31Zdeu
dc.date.available2012-04-04T13:38:31Zdeu
dc.date.issued2012-03
dc.description.abstractProstate cancer (PCa) is the most commonly diagnosed type of cancer in men in western industrialized countries. As a public health burden, the need for the invention of new cost-saving PCa immunotherapies is apparent. In this study, we present a DNA vaccine encoding for the prostate-specific antigen prostatic acid phosphatase (PAP) linked to the J-domain and the SV40 enhancer sequence. The PAP DNA vaccine induced a strong PAP-specific cellular immune response after electroporation (EP)-based delivery in C57BL/6 mice. Splenocytes from mice immunized with PAP recognized the naturally processed PAP epitopes, indicating that vaccination with the PAP-J gene broke its self-tolerance against PAP. Remarkably, DNA vaccination with PAP-J inhibited tumor growth in the Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) mouse model that closely resembled human PCa. Therefore, this study highlights a novel cancer immunotherapy approach with the potential to control PCa in clinical settings.eng
dc.description.versionpublished
dc.identifier.citationPubl. in: Molecular Therapy ; 20 (2012), 3. S. 555–564deu
dc.identifier.doi10.1038/mt.2011.241deu
dc.identifier.pmid22086231
dc.identifier.ppn499792637
dc.identifier.urihttp://kops.uni-konstanz.de/handle/123456789/18035
dc.language.isoengdeu
dc.legacy.dateIssued2012-04-04deu
dc.rightsterms-of-usedeu
dc.rights.urihttps://rightsstatements.org/page/InC/1.0/deu
dc.subject.ddc570deu
dc.titleAn artificial PAP gene breaks self-tolerance and promotes tumor regression in the TRAMP model for prostate carcinomaeng
dc.typeJOURNAL_ARTICLEdeu
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kops.citation.bibtex
@article{Spies2012-03artif-18035,
  year={2012},
  doi={10.1038/mt.2011.241},
  title={An artificial PAP gene breaks self-tolerance and promotes tumor regression in the TRAMP model for prostate carcinoma},
  number={3},
  volume={20},
  issn={1525-0016},
  journal={Molecular Therapy},
  pages={555--564},
  author={Spies, Elmar and Reichardt, Wilfried and Alvarez Salinas, Gerardo Omar and Gröttrup, Marcus and Öhlschläger, Peter}
}
kops.citation.iso690SPIES, Elmar, Wilfried REICHARDT, Gerardo Omar ALVAREZ SALINAS, Marcus GRÖTTRUP, Peter ÖHLSCHLÄGER, 2012. An artificial PAP gene breaks self-tolerance and promotes tumor regression in the TRAMP model for prostate carcinoma. In: Molecular Therapy. 2012, 20(3), pp. 555-564. ISSN 1525-0016. eISSN 1525-0024. Available under: doi: 10.1038/mt.2011.241deu
kops.citation.iso690SPIES, Elmar, Wilfried REICHARDT, Gerardo Omar ALVAREZ SALINAS, Marcus GRÖTTRUP, Peter ÖHLSCHLÄGER, 2012. An artificial PAP gene breaks self-tolerance and promotes tumor regression in the TRAMP model for prostate carcinoma. In: Molecular Therapy. 2012, 20(3), pp. 555-564. ISSN 1525-0016. eISSN 1525-0024. Available under: doi: 10.1038/mt.2011.241eng
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kops.sourcefieldMolecular Therapy. 2012, <b>20</b>(3), pp. 555-564. ISSN 1525-0016. eISSN 1525-0024. Available under: doi: 10.1038/mt.2011.241deu
kops.sourcefield.plainMolecular Therapy. 2012, 20(3), pp. 555-564. ISSN 1525-0016. eISSN 1525-0024. Available under: doi: 10.1038/mt.2011.241deu
kops.sourcefield.plainMolecular Therapy. 2012, 20(3), pp. 555-564. ISSN 1525-0016. eISSN 1525-0024. Available under: doi: 10.1038/mt.2011.241eng
kops.submitter.emailbrigitte.schanze@uni-konstanz.dedeu
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