Publikation:

Poly(ADP-ribose) polymerase-1, DNA repair and mammalian longevity

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2002

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Brabeck, Christine
Leake, Alan
Meyer, Ralph
Muiras, Marie-Laure
Pfeiffer, Ragen

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https://doi.org/10.1016/S0531-5565(02)00144-4
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Experimental Gerontology. Elsevier. 2002, 37(10-11), pp. 1203-1205. ISSN 0531-5565. eISSN 1873-6815. Available under: doi: 10.1016/S0531-5565(02)00144-4

Zusammenfassung

Cellular DNA repair activities can be expected to control the rate of the ageing process by keeping the steady-state levels of DNA damage, which is continuously induced by endogenous and exogenous damaging agents, at low levels. Poly(ADP-ribosyl)ation is one of the immediate biochemical reactions of eukaryotic cells to DNA damage and is functionally associated with DNA base-excision repair and strand break repair. Here we review the current state of the art concerning the relationship between DNA strand break repair, poly(ADP-ribosyl)ation, maintenance of genomic stability and mammalian life span.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Ageing, Longevity Poly(ADP-ribose) polymerase-1, DNA base-excision repair, Genomic instability

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ISO 690BÜRKLE, Alexander, Sascha BENEKE, Christine BRABECK, Alan LEAKE, Ralph MEYER, Marie-Laure MUIRAS, Ragen PFEIFFER, 2002. Poly(ADP-ribose) polymerase-1, DNA repair and mammalian longevity. In: Experimental Gerontology. Elsevier. 2002, 37(10-11), pp. 1203-1205. ISSN 0531-5565. eISSN 1873-6815. Available under: doi: 10.1016/S0531-5565(02)00144-4
BibTex
@article{Burkle2002PolyA-52162,
  year={2002},
  doi={10.1016/S0531-5565(02)00144-4},
  title={Poly(ADP-ribose) polymerase-1, DNA repair and mammalian longevity},
  number={10-11},
  volume={37},
  issn={0531-5565},
  journal={Experimental Gerontology},
  pages={1203--1205},
  author={Bürkle, Alexander and Beneke, Sascha and Brabeck, Christine and Leake, Alan and Meyer, Ralph and Muiras, Marie-Laure and Pfeiffer, Ragen}
}
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