Publikation:

Serine and one-carbon metabolisms bring new therapeutic venues in prostate cancer

Lade...
Vorschaubild

Dateien

Ganini_2-2a1jfns1b5tt3.pdf
Ganini_2-2a1jfns1b5tt3.pdfGröße: 1.79 MBDownloads: 203

Datum

2021

Autor:innen

Ganini, Carlo
Bertolo, Riccardo
Candi, Eleonora
Cappello, Angela
Cipriani, Chiara
Mauriello, Alessandro
Marani, Carla
Melino, Gerry
Bove, Pierluigi
et al.

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

ArXiv-ID

Internationale Patentnummer

Link zur Lizenz

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung
Open Access Hybrid
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Discover Oncology. Springer New York. 2021, 12(1), 45. ISSN 1868-8497. eISSN 1868-8500. Available under: doi: 10.1007/s12672-021-00440-7

Zusammenfassung

Serine and one-carbon unit metabolisms are essential biochemical pathways implicated in fundamental cellular functions such as proliferation, biosynthesis of important anabolic precursors and in general for the availability of methyl groups. These two distinct but interacting pathways are now becoming crucial in cancer, the de novo cytosolic serine pathway and the mitochondrial one-carbon metabolism. Apart from their role in physiological conditions, such as epithelial proliferation, the serine metabolism alterations are associated to several highly neoplastic proliferative pathologies. Accordingly, prostate cancer shows a deep rearrangement of its metabolism, driven by the dependency from the androgenic stimulus. Several new experimental evidence describes the role of a few of the enzymes involved in the serine metabolism in prostate cancer pathogenesis. The aim of this study is to analyze gene and protein expression data publicly available from large cancer specimens dataset, in order to further dissect the potential role of the abovementioned metabolism in the complex reshaping of the anabolic environment in this kind of neoplasm. The data suggest a potential role as biomarkers as well as in cancer therapy for the genes (and enzymes) belonging to the one-carbon metabolism in the context of prostatic cancer.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Serine, One-carbon metabolism, Prostate cancer metabolism

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690GANINI, Carlo, Ivano AMELIO, Riccardo BERTOLO, Eleonora CANDI, Angela CAPPELLO, Chiara CIPRIANI, Alessandro MAURIELLO, Carla MARANI, Gerry MELINO, Pierluigi BOVE, 2021. Serine and one-carbon metabolisms bring new therapeutic venues in prostate cancer. In: Discover Oncology. Springer New York. 2021, 12(1), 45. ISSN 1868-8497. eISSN 1868-8500. Available under: doi: 10.1007/s12672-021-00440-7
BibTex
@article{Ganini2021-12Serin-56525,
  year={2021},
  doi={10.1007/s12672-021-00440-7},
  title={Serine and one-carbon metabolisms bring new therapeutic venues in prostate cancer},
  number={1},
  volume={12},
  issn={1868-8497},
  journal={Discover Oncology},
  author={Ganini, Carlo and Amelio, Ivano and Bertolo, Riccardo and Candi, Eleonora and Cappello, Angela and Cipriani, Chiara and Mauriello, Alessandro and Marani, Carla and Melino, Gerry and Bove, Pierluigi},
  note={Article Number: 45}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/56525">
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/4.0/"/>
    <dc:contributor>Cappello, Angela</dc:contributor>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:contributor>Ganini, Carlo</dc:contributor>
    <dc:contributor>Marani, Carla</dc:contributor>
    <dc:contributor>Cipriani, Chiara</dc:contributor>
    <dcterms:issued>2021-12</dcterms:issued>
    <dc:creator>Ganini, Carlo</dc:creator>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-02-11T08:04:46Z</dcterms:available>
    <dc:creator>Amelio, Ivano</dc:creator>
    <dcterms:abstract xml:lang="eng">Serine and one-carbon unit metabolisms are essential biochemical pathways implicated in fundamental cellular functions such as proliferation, biosynthesis of important anabolic precursors and in general for the availability of methyl groups. These two distinct but interacting pathways are now becoming crucial in cancer, the de novo cytosolic serine pathway and the mitochondrial one-carbon metabolism. Apart from their role in physiological conditions, such as epithelial proliferation, the serine metabolism alterations are associated to several highly neoplastic proliferative pathologies. Accordingly, prostate cancer shows a deep rearrangement of its metabolism, driven by the dependency from the androgenic stimulus. Several new experimental evidence describes the role of a few of the enzymes involved in the serine metabolism in prostate cancer pathogenesis. The aim of this study is to analyze gene and protein expression data publicly available from large cancer specimens dataset, in order to further dissect the potential role of the abovementioned metabolism in the complex reshaping of the anabolic environment in this kind of neoplasm. The data suggest a potential role as biomarkers as well as in cancer therapy for the genes (and enzymes) belonging to the one-carbon metabolism in the context of prostatic cancer.</dcterms:abstract>
    <dcterms:title>Serine and one-carbon metabolisms bring new therapeutic venues in prostate cancer</dcterms:title>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:creator>Mauriello, Alessandro</dc:creator>
    <dc:contributor>Mauriello, Alessandro</dc:contributor>
    <dc:creator>Bertolo, Riccardo</dc:creator>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/56525/1/Ganini_2-2a1jfns1b5tt3.pdf"/>
    <dc:contributor>Bove, Pierluigi</dc:contributor>
    <dc:contributor>Melino, Gerry</dc:contributor>
    <dc:creator>Melino, Gerry</dc:creator>
    <dc:contributor>Bertolo, Riccardo</dc:contributor>
    <dc:rights>Attribution 4.0 International</dc:rights>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:contributor>Amelio, Ivano</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-02-11T08:04:46Z</dc:date>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/56525/1/Ganini_2-2a1jfns1b5tt3.pdf"/>
    <dc:language>eng</dc:language>
    <dc:contributor>Candi, Eleonora</dc:contributor>
    <dc:creator>Cipriani, Chiara</dc:creator>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/56525"/>
    <dc:creator>Bove, Pierluigi</dc:creator>
    <dc:creator>Marani, Carla</dc:creator>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:creator>Cappello, Angela</dc:creator>
    <dc:creator>Candi, Eleonora</dc:creator>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
Begutachtet
Unbekannt
Diese Publikation teilen