Publikation: Functional Properties of Na,K-ATPase, and Their Structural Implications, as Detected with Biophysical Techniques
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2001
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Karlish, Steven J. D.
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The Journal of Membrane Biology. 2001, 180(1), pp. 1-9. ISSN 0022-2631. eISSN 1432-1424. Available under: doi: 10.1007/s002320010053
Zusammenfassung
A full understanding of the molecular mechanism of ion transport and energetics of the Na,K-ATPase will require both structural and functional data. During recent years biophysical methods have provided a number of important pieces of information on ion binding and release and the charge transfer process. This allows the formulation of kinetic models of the transport process. Although a breakthrough has not been obtained due to the lack of detailed knowledge on the threedimensional structure with a resolution high enough to identify the ion-binding sites and the transport pathway, the functional information has structural implications that create constraints on possible mechanisms of active transport. Here we describe briefly contributions of some biophysical methods to our conceptual understanding of the ion transport process.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Sodium pump, Mechanistic properties, Binding sites, Ion transport, Structure-function relationship
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APELL, Hans-Jürgen, Steven J. D. KARLISH, 2001. Functional Properties of Na,K-ATPase, and Their Structural Implications, as Detected with Biophysical Techniques. In: The Journal of Membrane Biology. 2001, 180(1), pp. 1-9. ISSN 0022-2631. eISSN 1432-1424. Available under: doi: 10.1007/s002320010053BibTex
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year={2001},
doi={10.1007/s002320010053},
title={Functional Properties of Na,K-ATPase, and Their Structural Implications, as Detected with Biophysical Techniques},
number={1},
volume={180},
issn={0022-2631},
journal={The Journal of Membrane Biology},
pages={1--9},
author={Apell, Hans-Jürgen and Karlish, Steven J. D.}
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