Publikation: Oxidation of linoleic acid in low-density lipoprotein: An important event in atherogenesis
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Datum
2000
Autor:innen
Spiteller, Gerhard
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Angewandte Chemie International Edition. 2000, 39(3), pp. 585-589. ISSN 1433-7851. Available under: doi: 10.1002/(SICI)1521-3773(20000204)39:3<585::AID-ANIE585>3.0.CO;2-G
Zusammenfassung
Contrary to earlier views the main oxidation products of low-density lipoprotein (LDL) are derived from linoleic acid and not arachidonic acid, as determined by GC/MS investigations of the in vitro oxidation of LDL samples. A similar product spectrum, in which epoxyhydroxyoctadecenoic acids such as 1 and 2 have been identified for the first time, is obtained from minimally oxidized (that is, aged) LDL. Since this is still recognized by the LDL receptor, it is concluded that toxic oxidation products are introduced in endothelial cells in vivo and cause damage there.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
atherosclerosis, fatty acids, lipids, lipoproteins, oxygenations
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SPITELLER, Dieter, Gerhard SPITELLER, 2000. Oxidation of linoleic acid in low-density lipoprotein: An important event in atherogenesis. In: Angewandte Chemie International Edition. 2000, 39(3), pp. 585-589. ISSN 1433-7851. Available under: doi: 10.1002/(SICI)1521-3773(20000204)39:3<585::AID-ANIE585>3.0.CO;2-GBibTex
@article{Spiteller2000Oxida-15588, year={2000}, doi={10.1002/(SICI)1521-3773(20000204)39:3<585::AID-ANIE585>3.0.CO;2-G}, title={Oxidation of linoleic acid in low-density lipoprotein: An important event in atherogenesis}, number={3}, volume={39}, issn={1433-7851}, journal={Angewandte Chemie International Edition}, pages={585--589}, author={Spiteller, Dieter and Spiteller, Gerhard} }
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