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Oxidation of linoleic acid in low-density lipoprotein: An important event in atherogenesis

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2000

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Spiteller, Gerhard

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Angewandte Chemie International Edition. 2000, 39(3), pp. 585-589. ISSN 1433-7851. Available under: doi: 10.1002/(SICI)1521-3773(20000204)39:3<585::AID-ANIE585>3.0.CO;2-G

Zusammenfassung

Contrary to earlier views the main oxidation products of low-density lipoprotein (LDL) are derived from linoleic acid and not arachidonic acid, as determined by GC/MS investigations of the in vitro oxidation of LDL samples. A similar product spectrum, in which epoxyhydroxyoctadecenoic acids such as 1 and 2 have been identified for the first time, is obtained from minimally oxidized (that is, aged) LDL. Since this is still recognized by the LDL receptor, it is concluded that toxic oxidation products are introduced in endothelial cells in vivo and cause damage there.

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Fachgebiet (DDC)
570 Biowissenschaften, Biologie

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atherosclerosis, fatty acids, lipids, lipoproteins, oxygenations

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ISO 690SPITELLER, Dieter, Gerhard SPITELLER, 2000. Oxidation of linoleic acid in low-density lipoprotein: An important event in atherogenesis. In: Angewandte Chemie International Edition. 2000, 39(3), pp. 585-589. ISSN 1433-7851. Available under: doi: 10.1002/(SICI)1521-3773(20000204)39:3<585::AID-ANIE585>3.0.CO;2-G
BibTex
@article{Spiteller2000Oxida-15588,
  year={2000},
  doi={10.1002/(SICI)1521-3773(20000204)39:3<585::AID-ANIE585>3.0.CO;2-G},
  title={Oxidation of linoleic acid in low-density lipoprotein: An important event in atherogenesis},
  number={3},
  volume={39},
  issn={1433-7851},
  journal={Angewandte Chemie International Edition},
  pages={585--589},
  author={Spiteller, Dieter and Spiteller, Gerhard}
}
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