Defining the impact of childhood adversities on cognitive deficits in psychosis : An exploratory analysis

Lade...
Vorschaubild
Dateien
Schalinski_2-3bxxqsldf6wa4.pdf
Schalinski_2-3bxxqsldf6wa4.pdfGröße: 180.88 KBDownloads: 917
Datum
2018
Herausgeber:innen
Kontakt
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
ArXiv-ID
Internationale Patentnummer
EU-Projektnummer
DFG-Projektnummer
Forschungsförderung
Projekt
Open Access-Veröffentlichung
Sammlungen
Gesperrt bis
Titel in einer weiteren Sprache
Forschungsvorhaben
Organisationseinheiten
Zeitschriftenheft
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
Schizophrenia research. 2018, 192, pp. 351-356. ISSN 0920-9964. eISSN 1573-2509. Available under: doi: 10.1016/j.schres.2017.05.014
Zusammenfassung

Background
Exposure to adverse childhood experiences (ACE) and cognitive deficits are both prevalent in psychosis. While it has been repeatedly demonstrated that ACE contribute to cognitive dysfunctions, the specific nature of this contribution remains elusive. Recent evidence suggests that types of adversities during critical periods have deleterious effects on brain structures that are important for cognitive functioning. The present study sought to clarify which types of adversities experienced at which time during development aggravate cognitive deficits in psychosis.

Methods
Exposure to abuse and neglect during childhood and adolescence were retrospectively assessed in N = 168 adult individuals with psychotic disorder. Conditioned random forest regression was used to define the importance of type and timing of ACE for predicting domains of the MATRICS Consensus Cognitive Battery (MCCB).

Results
Significant importance of ACE was determined for 5 out of 7 MCCB domains. Particularly abuse at age 3 contributed to dysfunctional cognitive domains attention, learning, and working memory. Social cognition was related to neglect experienced at 11–12 years, and to cumulative ACE.

Conclusion
Abuse and neglect at periods when children spend substantial time in their families affect cognitive functioning, and hence aggravate dysfunction in psychosis. Results support the neurodevelopmental perspective on psychosis and the diagnostic value of type and timing of ACE.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
150 Psychologie
Schlagwörter
Sensitive period Neurodevelopment Childhood adversities Cognitive functioning
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690SCHALINSKI, Inga, Martin H. TEICHER, Almut CAROLUS, Brigitte ROCKSTROH, 2018. Defining the impact of childhood adversities on cognitive deficits in psychosis : An exploratory analysis. In: Schizophrenia research. 2018, 192, pp. 351-356. ISSN 0920-9964. eISSN 1573-2509. Available under: doi: 10.1016/j.schres.2017.05.014
BibTex
@article{Schalinski2018-02Defin-41562,
  year={2018},
  doi={10.1016/j.schres.2017.05.014},
  title={Defining the impact of childhood adversities on cognitive deficits in psychosis : An exploratory analysis},
  volume={192},
  issn={0920-9964},
  journal={Schizophrenia research},
  pages={351--356},
  author={Schalinski, Inga and Teicher, Martin H. and Carolus, Almut and Rockstroh, Brigitte}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/41562">
    <dc:contributor>Schalinski, Inga</dc:contributor>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/41562/3/Schalinski_2-3bxxqsldf6wa4.pdf"/>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-02-22T10:48:08Z</dc:date>
    <dc:contributor>Teicher, Martin H.</dc:contributor>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-02-22T10:48:08Z</dcterms:available>
    <dcterms:issued>2018-02</dcterms:issued>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/41562"/>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/41562/3/Schalinski_2-3bxxqsldf6wa4.pdf"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
    <dc:creator>Rockstroh, Brigitte</dc:creator>
    <dc:creator>Schalinski, Inga</dc:creator>
    <dc:creator>Teicher, Martin H.</dc:creator>
    <dc:language>eng</dc:language>
    <dc:creator>Carolus, Almut</dc:creator>
    <dc:contributor>Rockstroh, Brigitte</dc:contributor>
    <dc:contributor>Carolus, Almut</dc:contributor>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dcterms:abstract xml:lang="eng">Background&lt;br /&gt;Exposure to adverse childhood experiences (ACE) and cognitive deficits are both prevalent in psychosis. While it has been repeatedly demonstrated that ACE contribute to cognitive dysfunctions, the specific nature of this contribution remains elusive. Recent evidence suggests that types of adversities during critical periods have deleterious effects on brain structures that are important for cognitive functioning. The present study sought to clarify which types of adversities experienced at which time during development aggravate cognitive deficits in psychosis.&lt;br /&gt;&lt;br /&gt;Methods&lt;br /&gt;Exposure to abuse and neglect during childhood and adolescence were retrospectively assessed in N = 168 adult individuals with psychotic disorder. Conditioned random forest regression was used to define the importance of type and timing of ACE for predicting domains of the MATRICS Consensus Cognitive Battery (MCCB).&lt;br /&gt;&lt;br /&gt;Results&lt;br /&gt;Significant importance of ACE was determined for 5 out of 7 MCCB domains. Particularly abuse at age 3 contributed to dysfunctional cognitive domains attention, learning, and working memory. Social cognition was related to neglect experienced at 11–12 years, and to cumulative ACE.&lt;br /&gt;&lt;br /&gt;Conclusion&lt;br /&gt;Abuse and neglect at periods when children spend substantial time in their families affect cognitive functioning, and hence aggravate dysfunction in psychosis. Results support the neurodevelopmental perspective on psychosis and the diagnostic value of type and timing of ACE.</dcterms:abstract>
    <dcterms:title>Defining the impact of childhood adversities on cognitive deficits in psychosis : An exploratory analysis</dcterms:title>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
    <dc:rights>terms-of-use</dc:rights>
  </rdf:Description>
</rdf:RDF>
Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Kontakt
URL der Originalveröffentl.
Prüfdatum der URL
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Ja