@article{Muenzing2018-01larva-41543,
  year={2018},
  doi={10.1007/s12021-017-9349-6},
  title={larvalign: Aligning Gene Expression Patterns from the Larval Brain of Drosophila melanogaster},
  number={1},
  volume={16},
  issn={1539-2791},
  journal={Neuroinformatics},
  pages={65--80},
  author={Muenzing, Sascha E. A. and Strauch, Martin and Truman, James W. and Bühler, Katja and Thum, Andreas and Merhof, Dorit}
}

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    <dcterms:abstract xml:lang="eng">The larval brain of the fruit fly Drosophila melanogaster is a small, tractable model system for neuroscience. Genes for fluorescent marker proteins can be expressed in defined, spatially restricted neuron populations. Here, we introduce the methods for 1) generating a standard template of the larval central nervous system (CNS), 2) spatial mapping of expression patterns from different larvae into a reference space defined by the standard template. We provide a manually annotated gold standard that serves for evaluation of the registration framework involved in template generation and mapping. A method for registration quality assessment enables the automatic detection of registration errors, and a semi-automatic registration method allows one to correct registrations, which is a prerequisite for a high-quality, curated database of expression patterns. All computational methods are available within the larvalign software package: https://github.com/larvalign/larvalign/releases/tag/v1.0.</dcterms:abstract>
    <dc:creator>Bühler, Katja</dc:creator>
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    <dc:creator>Strauch, Martin</dc:creator>
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    <dc:creator>Thum, Andreas</dc:creator>
    <dc:creator>Merhof, Dorit</dc:creator>
    <dcterms:title>larvalign: Aligning Gene Expression Patterns from the Larval Brain of Drosophila melanogaster</dcterms:title>
    <dc:contributor>Bühler, Katja</dc:contributor>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/41543"/>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-02-21T13:37:07Z</dc:date>
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    <dc:creator>Muenzing, Sascha E. A.</dc:creator>
    <dc:rights>Attribution 4.0 International</dc:rights>
    <dc:contributor>Thum, Andreas</dc:contributor>
    <dc:contributor>Truman, James W.</dc:contributor>
    <dc:creator>Truman, James W.</dc:creator>
    <dcterms:issued>2018-01</dcterms:issued>
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    <dc:contributor>Merhof, Dorit</dc:contributor>
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    <dc:contributor>Muenzing, Sascha E. A.</dc:contributor>
    <dc:language>eng</dc:language>
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    <dc:contributor>Strauch, Martin</dc:contributor>
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