Publikation: Uncovering the Relationship between Selenium Status, Age, Health, and Dietary Habits : Insights from a Large Population Study including Nonagenarian Offspring from the MARK-AGE Project
Dateien
Datum
Autor:innen
Herausgeber:innen
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
URI (zitierfähiger Link)
DOI (zitierfähiger Link)
Internationale Patentnummer
Link zur Lizenz
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Core Facility der Universität Konstanz
Titel in einer weiteren Sprache
Publikationstyp
Publikationsstatus
Erschienen in
Zusammenfassung
An inadequate selenium (Se) status can accelerate the aging process, increasing the vulnerability to age-related diseases. The study aimed to investigate plasma Se and Se species in a large population, including 2200 older adults from the general population (RASIG), 514 nonagenarian offspring (GO), and 293 GO Spouses (SGO). Plasma Se levels in women exhibit an inverted U-shaped pattern, increasing with age until the post-menopausal period and then declining. Conversely, men exhibit a linear decline in plasma Se levels with age. Subjects from Finland had the highest plasma Se values, while those from Poland had the lowest ones. Plasma Se was influenced by fish and vitamin consumption, but there were no significant differences between RASIG, GO, and SGO. Plasma Se was positively associated with albumin, HDL, total cholesterol, fibrinogen, and triglycerides and negatively associated with homocysteine. Fractionation analysis showed that Se distribution among plasma selenoproteins is affected by age, glucometabolic and inflammatory factors, and being GO or SGO. These findings show that sex-specific, nutritional, and inflammatory factors play a crucial role in the regulation of Se plasma levels throughout the aging process and that the shared environment of GO and SGO plays a role in their distinctive Se fractionation.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
Schlagwörter
Konferenz
Rezension
Zitieren
ISO 690
GIACCONI, Robertina, Francesco PIACENZA, Valentina AVERSANO, Michele ZAMPIERI, Alexander BÜRKLE, Maria MORENO-VILLANUEVA, Martijn E. T. DOLLÉ, Eugène JANSEN, Tilman GRUNE, Efstathios S. GONOS, 2023. Uncovering the Relationship between Selenium Status, Age, Health, and Dietary Habits : Insights from a Large Population Study including Nonagenarian Offspring from the MARK-AGE Project. In: Nutrients. MDPI. 2023, 15(9), 2182. eISSN 2072-6643. Available under: doi: 10.3390/nu15092182BibTex
@article{Giacconi2023-05-04Uncov-67056, year={2023}, doi={10.3390/nu15092182}, title={Uncovering the Relationship between Selenium Status, Age, Health, and Dietary Habits : Insights from a Large Population Study including Nonagenarian Offspring from the MARK-AGE Project}, number={9}, volume={15}, journal={Nutrients}, author={Giacconi, Robertina and Piacenza, Francesco and Aversano, Valentina and Zampieri, Michele and Bürkle, Alexander and Moreno-Villanueva, Maria and Dollé, Martijn E. T. and Jansen, Eugène and Grune, Tilman and Gonos, Efstathios S.}, note={Article Number: 2182} }
RDF
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/67056"> <dc:creator>Jansen, Eugène</dc:creator> <dc:contributor>Dollé, Martijn E. T.</dc:contributor> <dc:creator>Aversano, Valentina</dc:creator> <dc:contributor>Grune, Tilman</dc:contributor> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/67056/1/Giacconi_2-4gq490z04aw47.pdf"/> <dc:contributor>Bürkle, Alexander</dc:contributor> <dc:creator>Zampieri, Michele</dc:creator> <dcterms:issued>2023-05-04</dcterms:issued> <dc:creator>Giacconi, Robertina</dc:creator> <dc:contributor>Aversano, Valentina</dc:contributor> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/35"/> <dc:contributor>Jansen, Eugène</dc:contributor> <dc:language>eng</dc:language> <dcterms:abstract>An inadequate selenium (Se) status can accelerate the aging process, increasing the vulnerability to age-related diseases. The study aimed to investigate plasma Se and Se species in a large population, including 2200 older adults from the general population (RASIG), 514 nonagenarian offspring (GO), and 293 GO Spouses (SGO). Plasma Se levels in women exhibit an inverted U-shaped pattern, increasing with age until the post-menopausal period and then declining. Conversely, men exhibit a linear decline in plasma Se levels with age. Subjects from Finland had the highest plasma Se values, while those from Poland had the lowest ones. Plasma Se was influenced by fish and vitamin consumption, but there were no significant differences between RASIG, GO, and SGO. Plasma Se was positively associated with albumin, HDL, total cholesterol, fibrinogen, and triglycerides and negatively associated with homocysteine. Fractionation analysis showed that Se distribution among plasma selenoproteins is affected by age, glucometabolic and inflammatory factors, and being GO or SGO. These findings show that sex-specific, nutritional, and inflammatory factors play a crucial role in the regulation of Se plasma levels throughout the aging process and that the shared environment of GO and SGO plays a role in their distinctive Se fractionation.</dcterms:abstract> <dc:rights>Attribution 4.0 International</dc:rights> <dc:contributor>Gonos, Efstathios S.</dc:contributor> <dcterms:title>Uncovering the Relationship between Selenium Status, Age, Health, and Dietary Habits : Insights from a Large Population Study including Nonagenarian Offspring from the MARK-AGE Project</dcterms:title> <dc:creator>Dollé, Martijn E. T.</dc:creator> <dc:creator>Gonos, Efstathios S.</dc:creator> <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/4.0/"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dc:creator>Bürkle, Alexander</dc:creator> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/67056"/> <dc:contributor>Moreno-Villanueva, Maria</dc:contributor> <dc:creator>Moreno-Villanueva, Maria</dc:creator> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dc:contributor>Giacconi, Robertina</dc:contributor> <dc:creator>Grune, Tilman</dc:creator> <dc:contributor>Piacenza, Francesco</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2023-06-02T14:06:54Z</dc:date> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/35"/> <dc:contributor>Zampieri, Michele</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/"/> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/67056/1/Giacconi_2-4gq490z04aw47.pdf"/> <dc:creator>Piacenza, Francesco</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2023-06-02T14:06:54Z</dcterms:available> </rdf:Description> </rdf:RDF>