Publikation:

Assessment of non-linear combination effect terms for drug-drug interactions

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Datum

2016

Autor:innen

Jusko, William J.

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URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-2-5ynyui4bq5f07
DOI (zitierfähiger Link)
https://doi.org/10.1007/s10928-016-9490-0
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Open Access-Veröffentlichung
Open Access Green

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Mathematik und Statistik: Publikationen
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Published

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Journal of Pharmacokinetics and Pharmacodynamics. 2016, 43(5), pp. 461-479. ISSN 0090-466X. eISSN 1573-8744. Available under: doi: 10.1007/s10928-016-9490-0

Zusammenfassung

Drugs interact with their targets in different ways. A diversity of modeling approaches exists to describe the combination effects of two drugs. We investigate several combination effect terms (CET) regarding their underlying mechanism based on drug-receptor binding kinetics, empirical and statistical summation principles and indirect response models. A list with properties is provided and the interrelationship of the CETs is analyzed. A method is presented to calculate the optimal drug concentration pair to produce the half-maximal combination effect. This work provides a comprehensive overview of typically applied CETs and should shed light into the question as to which CET is appropriate for application in pharmacokinetic/pharmacodynamic models to describe a specific drug-drug interaction mechanism.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
510 Mathematik

Schlagwörter

Drug–drug interaction; Combination therapy; Optimal concentration; Loewe Additivity; Bliss Independence

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ISO 690KOCH, Gilbert, Johannes SCHROPP, William J. JUSKO, 2016. Assessment of non-linear combination effect terms for drug-drug interactions. In: Journal of Pharmacokinetics and Pharmacodynamics. 2016, 43(5), pp. 461-479. ISSN 0090-466X. eISSN 1573-8744. Available under: doi: 10.1007/s10928-016-9490-0
BibTex
@article{Koch2016-10Asses-36991,
  year={2016},
  doi={10.1007/s10928-016-9490-0},
  title={Assessment of non-linear combination effect terms for drug-drug interactions},
  number={5},
  volume={43},
  issn={0090-466X},
  journal={Journal of Pharmacokinetics and Pharmacodynamics},
  pages={461--479},
  author={Koch, Gilbert and Schropp, Johannes and Jusko, William J.}
}
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