Publikation:

Genomic basis of striking fin shapes and colours in the fighting fish

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2021

Autor:innen

Wang, Le
Sun, Fei
Wan, Zi Yi
Ye, Baoqing
Wen, Yanfei
Liu, Huiming
Piferrer, Francesc
Schartl, Manfred
Yue, Gen Hua
et al.

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Molecular Biology and Evolution. Oxford University Press. 2021, 38(8), pp. 3383-3396. ISSN 0737-4038. eISSN 1537-1719. Available under: doi: 10.1093/molbev/msab110

Zusammenfassung

Resolving the genomic basis underlying phenotypic variations is a question of great importance in evolutionary biology. However, understanding how genotypes determine the phenotypes is still challenging. Centuries of artificial selective breeding for beauty and aggression resulted in a plethora of colors, long fin varieties, and hyper-aggressive behavior in the air-breathing Siamese fighting fish (Betta splendens), supplying an excellent system for studying the genomic basis of phenotypic variations. Combining whole genome sequencing, QTL mapping, genome-wide association studies and genome editing, we investigated the genomic basis of huge morphological variation in fins and striking differences in coloration in the fighting fish. Results revealed that the double tail, elephant ear, albino and fin spot mutants each were determined by single major-effect loci. The elephant ear phenotype was likely related to differential expression of a potassium ion channel gene, kcnh8. The albinotic phenotype was likely linked to a cis-regulatory element acting on the mitfa gene and the double tail mutant was suggested to be caused by a deletion in a zic1/zic4 co-enhancer. Our data highlight that major loci and cis-regulatory elements play important roles in bringing about phenotypic innovations and establish Bettas as new powerful model to study the genomic basis of evolved changes.

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Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Domestication, evolution, major-effect loci, cis-regulation; mitfa; zic1/zic4

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ISO 690WANG, Le, Fei SUN, Zi Yi WAN, Baoqing YE, Yanfei WEN, Huiming LIU, Francesc PIFERRER, Manfred SCHARTL, Axel MEYER, Gen Hua YUE, 2021. Genomic basis of striking fin shapes and colours in the fighting fish. In: Molecular Biology and Evolution. Oxford University Press. 2021, 38(8), pp. 3383-3396. ISSN 0737-4038. eISSN 1537-1719. Available under: doi: 10.1093/molbev/msab110
BibTex
@article{Wang2021-08-01Genom-53523,
  year={2021},
  doi={10.1093/molbev/msab110},
  title={Genomic basis of striking fin shapes and colours in the fighting fish},
  number={8},
  volume={38},
  issn={0737-4038},
  journal={Molecular Biology and Evolution},
  pages={3383--3396},
  author={Wang, Le and Sun, Fei and Wan, Zi Yi and Ye, Baoqing and Wen, Yanfei and Liu, Huiming and Piferrer, Francesc and Schartl, Manfred and Meyer, Axel and Yue, Gen Hua}
}
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