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The Cre/Lox System to Assess the Development of the Mouse Brain

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2020

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Rijli, Filippo M.

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https://doi.org/10.1007/978-1-4939-9732-9_28
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SPRECHER, Simon G., ed.. Brain Development : Methods and Protocols. New York, NY: Springer, Humana Press, 2020, pp. 491-512. Methods in Molecular Biology. 2047. ISBN 978-1-4939-9731-2. Available under: doi: 10.1007/978-1-4939-9732-9_28

Zusammenfassung

Cre-mediated recombination has become a powerful tool to confine gene deletions (conditional knockouts) or overexpression of genes (conditional knockin/overexpression). By spatiotemporal restriction of genetic manipulations, major problems of classical knockouts such as embryonic lethality or pleiotropy can be circumvented. Furthermore, Cre-mediated recombination has broad applications in the analysis of the cellular behavior of subpopulations and cell types as well as for genetic fate mapping. This chapter gives an overview about applications for the Cre/LoxP system and their execution.

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570 Biowissenschaften, Biologie

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ISO 690KRATOCHWIL, Claudius F., Filippo M. RIJLI, 2020. The Cre/Lox System to Assess the Development of the Mouse Brain. In: SPRECHER, Simon G., ed.. Brain Development : Methods and Protocols. New York, NY: Springer, Humana Press, 2020, pp. 491-512. Methods in Molecular Biology. 2047. ISBN 978-1-4939-9731-2. Available under: doi: 10.1007/978-1-4939-9732-9_28
BibTex
@incollection{Kratochwil2020CreLo-50797,
  year={2020},
  doi={10.1007/978-1-4939-9732-9_28},
  title={The Cre/Lox System to Assess the Development of the Mouse Brain},
  number={2047},
  isbn={978-1-4939-9731-2},
  publisher={Springer, Humana Press},
  address={New York, NY},
  series={Methods in Molecular Biology},
  booktitle={Brain Development : Methods and Protocols},
  pages={491--512},
  editor={Sprecher, Simon G.},
  author={Kratochwil, Claudius F. and Rijli, Filippo M.}
}
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