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N-glycosylation profiling of plasma provides evidence for accelerated physiological aging in post-traumatic stress disorder

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Moreno-Villanueva_257056.pdf
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2013

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Vanhooren, Valerie
Kolassa, Stephan
Libert, Claude

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http://nbn-resolving.de/urn:nbn:de:bsz:352-257056
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https://doi.org/10.1038/tp.2013.93
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Translational Psychiatry. 2013, 3(10), e320. eISSN 2158-3188. Available under: doi: 10.1038/tp.2013.93

Zusammenfassung

The prevalence of age-related diseases is increased in individuals with post-traumatic stress disorder (PTSD). However, the underlying biological mechanisms are still unclear. N-glycosylation is an age-dependent process, identified as a biomarker for physiological aging (GlycoAge Test). To investigate whether traumatic stress accelerates the aging process, we analyzed the N-glycosylation profile in n=13 individuals with PTSD, n=9 trauma-exposed individuals and in n=10 low-stress control subjects. Individuals with PTSD and trauma-exposed individuals presented an upward shift in the GlycoAge Test, equivalent to an advancement of the aging process by 15 additional years. Trauma-exposed individuals presented an intermediate N-glycosylation profile positioned between severely traumatized individuals with PTSD and low-stress control subjects. In conclusion, our data suggest that cumulative exposure to traumatic stressors accelerates the process of physiological aging.

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150 Psychologie

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ISO 690MORENO-VILLANUEVA, Maria, Julia MORATH, Valerie VANHOOREN, Thomas ELBERT, Stephan KOLASSA, Claude LIBERT, Alexander BÜRKLE, Iris-Tatjana KOLASSA, 2013. N-glycosylation profiling of plasma provides evidence for accelerated physiological aging in post-traumatic stress disorder. In: Translational Psychiatry. 2013, 3(10), e320. eISSN 2158-3188. Available under: doi: 10.1038/tp.2013.93
BibTex
@article{MorenoVillanueva2013Nglyc-25705,
  year={2013},
  doi={10.1038/tp.2013.93},
  title={N-glycosylation profiling of plasma provides evidence for accelerated physiological aging in post-traumatic stress disorder},
  number={10},
  volume={3},
  journal={Translational Psychiatry},
  author={Moreno-Villanueva, Maria and Morath, Julia and Vanhooren, Valerie and Elbert, Thomas and Kolassa, Stephan and Libert, Claude and Bürkle, Alexander and Kolassa, Iris-Tatjana},
  note={Article Number: e320}
}
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