Publikation: Detectable concentrations of Fas ligand in cerebrospinal fluid after severe head injury
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Datum
1997
Autor:innen
Ertel, Wolfgang
Keel, Marius
Stocker, Reto
Imhof, Hans-Georg
Steckholzer, Ursula
Tanaka, Masako
Trentz, Otmar
Nagata, Shigekazu
Herausgeber:innen
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Journal of Neuroimmunology. 1997, 80(1/2), pp. 93-96. ISSN 0165-5728. Available under: doi: 10.1016/S0165-5728(97)00139-2
Zusammenfassung
When the cell surface molecule Fas is triggered by its agonist Fas ligand the result is apoptosis of these cells and tissue destruction. To elucidate the pathophysiological relevance of Fas ligand in patients with cerebral oedema caused by trauma, we examined its concentrations in cerebrospinal fluid in 18 patients using specific ELISA. Serum and cerebrospinal fluid from healthy people and injured patients without head trauma did not contain detectable Fas ligand. In contrast, cerebrospinal fluid from patients with severe brain injury contained high concentrations of Fas ligand without detectable concentrations in serum. Soluble Fas ligand concentrations in cerebrospinal fluid correlated significantly with severity of brain injury. The Fas-Fas ligand-system may have a pivotal role in causing oedema and local tissue destruction in the brain after severe head injury.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Fas antigen, Fas ligand, Apoptosis, Head injury, Brain oedema, Cerebrospinal fluid
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ISO 690
ERTEL, Wolfgang, Marius KEEL, Reto STOCKER, Hans-Georg IMHOF, Marcel LEIST, Ursula STECKHOLZER, Masako TANAKA, Otmar TRENTZ, Shigekazu NAGATA, 1997. Detectable concentrations of Fas ligand in cerebrospinal fluid after severe head injury. In: Journal of Neuroimmunology. 1997, 80(1/2), pp. 93-96. ISSN 0165-5728. Available under: doi: 10.1016/S0165-5728(97)00139-2BibTex
@article{Ertel1997Detec-6706,
year={1997},
doi={10.1016/S0165-5728(97)00139-2},
title={Detectable concentrations of Fas ligand in cerebrospinal fluid after severe head injury},
number={1/2},
volume={80},
issn={0165-5728},
journal={Journal of Neuroimmunology},
pages={93--96},
author={Ertel, Wolfgang and Keel, Marius and Stocker, Reto and Imhof, Hans-Georg and Leist, Marcel and Steckholzer, Ursula and Tanaka, Masako and Trentz, Otmar and Nagata, Shigekazu}
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