Publikation:

Arginine methylation of the B cell antigen receptor promotes differentiation

Vorschaubild

Dateien

Zu diesem Dokument gibt es keine Dateien.

Datum

2010

Autor:innen

Infantino, Simona
Benz, Beate
Jung, Manfred
Schneider, Robert
Reth, Michael

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

URI (zitierfähiger Link)
DOI (zitierfähiger Link)
https://doi.org/10.1084/jem.20091303
ArXiv-ID

Internationale Patentnummer

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung

Sammlungen

Biologie: Publikationen
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

The Journal of Experimental Medicine : JEM. 2010, 207(4), pp. 711-719. ISSN 0022-1007. eISSN 1540-9538. Available under: doi: 10.1084/jem.20091303

Zusammenfassung

Signals processed through the B cell antigen receptor (BCR) control both the proliferation and differentiation of B lymphocytes. How these different signaling modes are established at the BCR is poorly understood. We show that a conserved arginine in the tail sequence of the Igalpha subunit of the BCR is methylated by the protein arginine methyltransferase 1. This modification negatively regulates the calcium and PI-3 kinase pathways of the BCR while promoting signals leading to B cell differentiation. Thus, Igalpha arginine methylation can play an important role in specifying the outcome of BCR signaling.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690INFANTINO, Simona, Beate BENZ, Tanja WALDMANN, Manfred JUNG, Robert SCHNEIDER, Michael RETH, 2010. Arginine methylation of the B cell antigen receptor promotes differentiation. In: The Journal of Experimental Medicine : JEM. 2010, 207(4), pp. 711-719. ISSN 0022-1007. eISSN 1540-9538. Available under: doi: 10.1084/jem.20091303
BibTex
@article{Infantino2010-04-12Argin-38525,
  year={2010},
  doi={10.1084/jem.20091303},
  title={Arginine methylation of the B cell antigen receptor promotes differentiation},
  number={4},
  volume={207},
  issn={0022-1007},
  journal={The Journal of Experimental Medicine : JEM},
  pages={711--719},
  author={Infantino, Simona and Benz, Beate and Waldmann, Tanja and Jung, Manfred and Schneider, Robert and Reth, Michael}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/38525">
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:creator>Reth, Michael</dc:creator>
    <dc:contributor>Reth, Michael</dc:contributor>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/38525"/>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-04-20T06:56:48Z</dcterms:available>
    <dc:creator>Waldmann, Tanja</dc:creator>
    <dc:contributor>Infantino, Simona</dc:contributor>
    <dcterms:issued>2010-04-12</dcterms:issued>
    <dc:contributor>Benz, Beate</dc:contributor>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:creator>Schneider, Robert</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dcterms:abstract xml:lang="eng">Signals processed through the B cell antigen receptor (BCR) control both the proliferation and differentiation of B lymphocytes. How these different signaling modes are established at the BCR is poorly understood. We show that a conserved arginine in the tail sequence of the Igalpha subunit of the BCR is methylated by the protein arginine methyltransferase 1. This modification negatively regulates the calcium and PI-3 kinase pathways of the BCR while promoting signals leading to B cell differentiation. Thus, Igalpha arginine methylation can play an important role in specifying the outcome of BCR signaling.</dcterms:abstract>
    <dc:contributor>Schneider, Robert</dc:contributor>
    <dc:contributor>Waldmann, Tanja</dc:contributor>
    <dc:creator>Infantino, Simona</dc:creator>
    <dc:contributor>Jung, Manfred</dc:contributor>
    <dc:creator>Jung, Manfred</dc:creator>
    <dcterms:title>Arginine methylation of the B cell antigen receptor promotes differentiation</dcterms:title>
    <dc:creator>Benz, Beate</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-04-20T06:56:48Z</dc:date>
    <dc:language>eng</dc:language>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Diese Publikation teilen