Publikation:

A Neural Circuit Arbitrates between Persistence and Withdrawal in Hungry Drosophila

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Datum

2019

Autor:innen

De Backer, Jean-Francois
Siju, K. P.
Wosniack, Marina E.
Lewis, Laurence P.
Gansen, Benedikt
Schlegel, Philipp
Edmondson-Stait, Amelia
Grunwald Kadow, Ilona C.
et al.

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URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-2-7v5unsgxik4k5
DOI (zitierfähiger Link)
https://doi.org/10.1016/j.neuron.2019.07.028
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Internationale Patentnummer

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CC BY-NC-ND 4.0

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Open Access-Veröffentlichung
Open Access Hybrid

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Biologie: Publikationen
Core Facility der Universität Konstanz

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Titel in einer weiteren Sprache

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Zeitschriftenartikel
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Published

Erschienen in

Neuron. Cell Press. 2019, 104(3), pp. 544-558.e6. ISSN 0896-6273. eISSN 1097-4199. Available under: doi: 10.1016/j.neuron.2019.07.028

Zusammenfassung

In pursuit of food, hungry animals mobilize significant energy resources and overcome exhaustion and fear. How need and motivation control the decision to continue or change behavior is not understood. Using a single fly treadmill, we show that hungry flies persistently track a food odor and increase their effort over repeated trials in the absence of reward suggesting that need dominates negative experience. We further show that odor tracking is regulated by two mushroom body output neurons (MBONs) connecting the MB to the lateral horn. These MBONs, together with dopaminergic neurons and Dop1R2 signaling, control behavioral persistence. Conversely, an octopaminergic neuron, VPM4, which directly innervates one of the MBONs, acts as a brake on odor tracking by connecting feeding and olfaction. Together, our data suggest a function for the MB in internal state-dependent expression of behavior that can be suppressed by external inputs conveying a competing behavioral drive.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

goal-directed behavior, olfactory system, dopamine, mushroom body, Drosophila melanogaster, octopamine, persistence, foraging, DopR2, learning

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ISO 690SAYIN, Sercan, Jean-Francois DE BACKER, K. P. SIJU, Marina E. WOSNIACK, Laurence P. LEWIS, Lisa-Marie FRISCH, Benedikt GANSEN, Philipp SCHLEGEL, Amelia EDMONDSON-STAIT, Ilona C. GRUNWALD KADOW, 2019. A Neural Circuit Arbitrates between Persistence and Withdrawal in Hungry Drosophila. In: Neuron. Cell Press. 2019, 104(3), pp. 544-558.e6. ISSN 0896-6273. eISSN 1097-4199. Available under: doi: 10.1016/j.neuron.2019.07.028
BibTex
@article{Sayin2019Neura-57540,
  year={2019},
  doi={10.1016/j.neuron.2019.07.028},
  title={A Neural Circuit Arbitrates between Persistence and Withdrawal in Hungry Drosophila},
  number={3},
  volume={104},
  issn={0896-6273},
  journal={Neuron},
  pages={544--558.e6},
  author={Sayin, Sercan and De Backer, Jean-Francois and Siju, K. P. and Wosniack, Marina E. and Lewis, Laurence P. and Frisch, Lisa-Marie and Gansen, Benedikt and Schlegel, Philipp and Edmondson-Stait, Amelia and Grunwald Kadow, Ilona C.}
}
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Interner Vermerk

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