Towards a functional connectome in Drosophila

Vogt, Katrin

Towards a functional connectome in Drosophila

Dateien

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Datum

2020

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Journal of Neurogenetics. Taylor & Francis. 2020, 34(1), pp. 156-161. ISSN 0167-7063. eISSN 1563-5260. Available under: doi: 10.1080/01677063.2020.1712598

Zusammenfassung

The full functionality of the brain is determined by its molecular, cellular and circuit structure. Modern neuroscience now prioritizes the mapping of whole brain connectomes by detecting all direct neuron to neuron synaptic connections, a feat first accomplished for C. elegans, a full reconstruction of a 302-neuron nervous system. Efforts at Janelia Research Campus will soon reconstruct the whole brain connectomes of a larval and an adult Drosophila. These connectomes will provide a framework for incorporating detailed neural circuit information that Drosophila neuroscientists have gathered over decades. But when viewed in the context of a whole brain, it becomes difficult to isolate the contributions of distinct circuits, whether sensory systems or higher brain regions. The complete wiring diagram tells us that sensory information is not only processed in separate channels, but that even the earliest sensory layers are strongly synaptically interconnected. In the higher brain, long-range projections densely interconnect major brain regions and convergence centers that integrate input from different sensory systems. Furthermore, we also need to understand the impact of neuronal communication beyond direct synaptic modulation. Nevertheless, all of this can be pursued with Drosophila, combining connectomics with a diverse array of genetic tools and behavioral paradigms that provide effective approaches to entire brain function.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

Connectomics, Drosophila, neurogenetics, behavior

Zitieren

ISO 690

VOGT, Katrin, 2020. Towards a functional connectome in Drosophila. In: Journal of Neurogenetics. Taylor & Francis. 2020, 34(1), pp. 156-161. ISSN 0167-7063. eISSN 1563-5260. Available under: doi: 10.1080/01677063.2020.1712598

BibTex

@article{Vogt2020Towar-54231,
  year={2020},
  doi={10.1080/01677063.2020.1712598},
  title={Towards a functional connectome in Drosophila},
  number={1},
  volume={34},
  issn={0167-7063},
  journal={Journal of Neurogenetics},
  pages={156--161},
  author={Vogt, Katrin}
}

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