Publikation:

Integrin-β4 is a novel transcriptional target of TAp73

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2018

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Xie, Ningxia
Vikhreva, Polina
Annicchiarico-Petruzzelli, Margherita
Barlev, Nicolai
Knight, Richard A.
Melino, Gerry

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https://doi.org/10.1080/15384101.2017.1403684
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Biologie: Publikationen
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Cell Cycle. Taylor & Francis. 2018, 17(5), pp. 589-594. ISSN 1538-4101. eISSN 1551-4005. Available under: doi: 10.1080/15384101.2017.1403684

Zusammenfassung

As a member of p53 family, p73 has attracted intense investigations due to its structural and functional similarities to p53. Among more than ten p73 variants, the transactivation (TA) domain-containing isoform TAp73 is the one that imitates the p53's behavior most. TAp73 induces apoptosis and cell cycle arrest, which endows it the capacity of tumour suppression. Also, it can exert diverse biological influences on cells through activating a complex and context dependent transcriptional programme. The transcriptional activities further broaden its roles in more intricate biological processes. In this article, we report that p73 is a positive regulator of a cell adhesion related gene named integrin β4 (ITGB4). This finding may have implications for the dissection of the biological mechanisms underlining p73 functions.

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Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

p53 family, Integrins, cell interaction, p73, oncosupression, cancer cells, adhesion and migration, oncogenes and tumor suppressors, transcription factors

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ISO 690XIE, Ningxia, Polina VIKHREVA, Margherita ANNICCHIARICO-PETRUZZELLI, Ivano AMELIO, Nicolai BARLEV, Richard A. KNIGHT, Gerry MELINO, 2018. Integrin-β4 is a novel transcriptional target of TAp73. In: Cell Cycle. Taylor & Francis. 2018, 17(5), pp. 589-594. ISSN 1538-4101. eISSN 1551-4005. Available under: doi: 10.1080/15384101.2017.1403684
BibTex
@article{Xie2018Integ-56665,
  year={2018},
  doi={10.1080/15384101.2017.1403684},
  title={Integrin-β4 is a novel transcriptional target of TAp73},
  number={5},
  volume={17},
  issn={1538-4101},
  journal={Cell Cycle},
  pages={589--594},
  author={Xie, Ningxia and Vikhreva, Polina and Annicchiarico-Petruzzelli, Margherita and Amelio, Ivano and Barlev, Nicolai and Knight, Richard A. and Melino, Gerry}
}
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