Publikation:

Analysis of SMAD1/5 target genes in a sea anemone reveals ZSWIM4-6 as a novel BMP signaling modulator

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Knabl_2-95kyniektwji7.pdf
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Datum

2024

Autor:innen

Knabl, Paul
Schauer, Alexandra
Pomreinke, Autumn P.
Zimmermann, Bob
Rogers, Katherine W.
Genikhovich, Grigory

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European Union (EU): 637840
European Union (EU): 863952
European Research Council: 637840
European Research Council: 863952

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Open Access-Veröffentlichung
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Published

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eLife. eLife Sciences Publications. 2024, 13, e80803. eISSN 2050-084X. Verfügbar unter: doi: 10.7554/elife.80803

Zusammenfassung

BMP signaling has a conserved function in patterning the dorsal-ventral body axis in Bilateria and the directive axis in anthozoan cnidarians. So far, cnidarian studies have focused on the role of different BMP signaling network components in regulating pSMAD1/5 gradient formation. Much less is known about the target genes downstream of BMP signaling. To address this, we generated a genome-wide list of direct pSMAD1/5 target genes in the anthozoan Nematostella vectensis, several of which were conserved in Drosophila and Xenopus. Our ChIP-seq analysis revealed that many of the regulatory molecules with documented bilaterally symmetric expression in Nematostella are directly controlled by BMP signaling. We identified several so far uncharacterized BMP-dependent transcription factors and signaling molecules, whose bilaterally symmetric expression may be indicative of their involvement in secondary axis patterning. One of these molecules is zswim4-6, which encodes a novel nuclear protein that can modulate the pSMAD1/5 gradient and potentially promote BMP-dependent gene repression.

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570 Biowissenschaften, Biologie

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ISO 690KNABL, Paul, Alexandra SCHAUER, Autumn P. POMREINKE, Bob ZIMMERMANN, Katherine W. ROGERS, Daniel CAPEK, Patrick MÜLLER, Grigory GENIKHOVICH, 2024. Analysis of SMAD1/5 target genes in a sea anemone reveals ZSWIM4-6 as a novel BMP signaling modulator. In: eLife. eLife Sciences Publications. 2024, 13, e80803. eISSN 2050-084X. Verfügbar unter: doi: 10.7554/elife.80803
BibTex
@article{Knabl2024-02-07Analy-70010,
  year={2024},
  doi={10.7554/elife.80803},
  title={Analysis of SMAD1/5 target genes in a sea anemone reveals ZSWIM4-6 as a novel BMP signaling modulator},
  volume={13},
  journal={eLife},
  author={Knabl, Paul and Schauer, Alexandra and Pomreinke, Autumn P. and Zimmermann, Bob and Rogers, Katherine W. and Capek, Daniel and Müller, Patrick and Genikhovich, Grigory},
  note={Article Number: e80803}
}
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