Structural advances on titin : towards an atomic understanding of multi-domain functions in myofilament mechanics and scaffolding

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2015
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Zacharchenko, Thomas
Castelmur, Eleonore von
Rigden, Daniel J.
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Biochemical Society Transactions. 2015, 43(5), pp. 850-855. ISSN 0300-5127. eISSN 1470-8752. Available under: doi: 10.1042/BST20150084
Zusammenfassung

Titin is a gigantic filamentous protein of the muscle sarcomere that plays roles in myofibril mechanics and homoeostasis. 3D-structures of multi-domain fragments of titin are now available that start revealing the molecular mechanisms governing its mechanical and scaffolding functions. This knowledge is now being translated into the fabrication of self-assembling biopolymers. Here we review the structural advances on titin, the novel concepts derived from these and the emerging translational avenues.

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570 Biowissenschaften, Biologie
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ISO 690ZACHARCHENKO, Thomas, Eleonore von CASTELMUR, Daniel J. RIGDEN, Olga MAYANS, 2015. Structural advances on titin : towards an atomic understanding of multi-domain functions in myofilament mechanics and scaffolding. In: Biochemical Society Transactions. 2015, 43(5), pp. 850-855. ISSN 0300-5127. eISSN 1470-8752. Available under: doi: 10.1042/BST20150084
BibTex
@article{Zacharchenko2015-10-01Struc-32253,
  year={2015},
  doi={10.1042/BST20150084},
  title={Structural advances on titin : towards an atomic understanding of multi-domain functions in myofilament mechanics and scaffolding},
  number={5},
  volume={43},
  issn={0300-5127},
  journal={Biochemical Society Transactions},
  pages={850--855},
  author={Zacharchenko, Thomas and Castelmur, Eleonore von and Rigden, Daniel J. and Mayans, Olga}
}
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